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Literature DB >> 7140976

Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptide.

D Bataille, A M Coudray, M Carlqvist, G Rosselin, V Mutt.

Abstract

A 37 amino acid-peptide has been isolated from porcine jejuno-ileum on the basis of its glucagon-like activity in liver (interaction with glucagon-binding sites and activation of adenylate cyclase) using gel filtration, ion-exchange and high-performance liquid chromatography. Depending on the criteria chosen, this peptide is referred to as either 'bioactive enteroglucagon' (activity in liver), 'oxyntomodulin' (specific action in gastric oxyntic glands) or 'glucagon-37' (chemical structure).

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7140976 DOI： 10.1016/0014-5793(82)80708-4

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

15 in total

Review 1. Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005.

Authors: J J Holst
Journal: Diabetologia Date: 2006-01-14 Impact factor: 10.122

2. Oxyntomodulin reduces hydromineral transport through rat small intestine.

Authors: F Beauclair; B Eto; D Pansu; G Rodier; T Mochizuki; J Martinez; D Bataille; C Jarrousse
Journal: Dig Dis Sci Date: 1998-08 Impact factor: 3.199

3. Glucagon receptors along the nephron: [125I]glucagon binding in rat tubules.

Authors: D Butlen; F Morel
Journal: Pflugers Arch Date: 1985-08 Impact factor: 3.657

Review 4. Proglucagon-derived peptides: nomenclature, biosynthetic relationships and physiological roles.

Authors: J M Conlon
Journal: Diabetologia Date: 1988-08 Impact factor: 10.122

5. Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions.

Authors: B Schjoldager; P E Mortensen; J Myhre; J Christiansen; J J Holst
Journal: Dig Dis Sci Date: 1989-09 Impact factor: 3.199

6. A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei.

Authors: J M Conlon; E Dafgård; S Falkmer; L Thim
Journal: Biochem J Date: 1987-08-01 Impact factor: 3.857

Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptide.

Review 1. Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005.

2. Oxyntomodulin reduces hydromineral transport through rat small intestine.

3. Glucagon receptors along the nephron: [125I]glucagon binding in rat tubules.

Review 4. Proglucagon-derived peptides: nomenclature, biosynthetic relationships and physiological roles.

5. Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions.

6. A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei.

7. Identification of glucagon receptors in rat brain.

8. N-acetyl oxyntomodulin30-37: pharmacokinetics and activity on gastric acid secretion.

9. Glucagon-related peptides in the human gastrointestinal mucosa.

10. Enteroglucagon. A putative humoral factor inducing pancreatic hyperplasia after proximal small bowel resection.