Literature DB >> 7140818

The interactions of platelet-derived mediators on isolated canine coronary arteries.

K M Mullane, G Bradley, S Moncada.   

Abstract

The interactions of 5-hydroxytryptamine (5-HT) and a thromboxane A2 mimetic, U44069, were investigated on rings of canine coronary arteries. 5-HT (10(-8) - 10(-5) M) and U44069 (10(-9) - 10(-6) M) produce coronary vasoconstriction which is potentiated by indomethacin (3 X 10(-6) M). In the presence of 10(-9) M 5-HT, U44069-induced vasoconstriction is enhanced. Similarly, 10(-9) M U44069 enhances the effects of 5-HT. In both cases this potentiation is greatest in the presence of indomethacin. Synergism between the platelet-derived mediators could contribute to coronary vasospasm and myocardial ischaemia.

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Year:  1982        PMID： 7140818     DOI： 10.1016/0014-2999(82)90166-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Release of a neutrophil-derived vasoconstrictor agent which augments platelet-induced contractions of blood vessels in vitro.

Authors:  W C Sessa; K M Mullane
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

2.  Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.

Authors:  D S Houston; J T Shepherd; P M Vanhoutte
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

3.  Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

4.  Suppression of reperfusion-induced arrhythmias with combined administration of 5-HT2 and thromboxane A2 antagonists.

Authors:  L A Shaw; S J Coker
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

5.  Disturbed lipid metabolism in diabetic coronary vessels.

Authors:  M Z Koltai; P Rösen; P Hadházy; Z Aranyi; G Ballagi-Pordány; G Pogátsa
Journal:  Mol Cell Biochem       Date:  1992-02-12       Impact factor: 3.396

6.  Effects of U46619 on contractions to 5-HT, sumatriptan and methysergide in canine coronary artery and saphenous vein in vitro.

Authors:  B K Kemp; T M Cocks
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739
  6 in total

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