Literature DB >> 7140700

MEHP/DEHP: gonadal toxicity and effects on rodent accessory sex organs.

J A Thomas, K A Curto, M J Thomas.   

Abstract

The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be particularly sensitive to PAE-induced zinc depletion. PAE-induced changes in male reproductive organs were more evident in the rat than in the mouse. Some of the effects of MEHP can be demonstrated in vitro since it can alter the uptake of 65Zn in rodent gonads and accessory sex organs.

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Year:  1982        PMID： 7140700      PMCID： PMC1569004          DOI： 10.1289/ehp.824585

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  16 in total

1.  Studies on dibutyl phthalate-induced testicular atrophy in the rat: effect on zinc metabolism.

Authors:  B R Cater; M W Cook; S D Gangolli; P Grasso
Journal:  Toxicol Appl Pharmacol       Date:  1977-09       Impact factor: 4.219

Review 2.  A review of the biological effects of di-(2-ethylhexyl) phthalate.

Authors:  J A Thomas; T D Darby; R F Wallin; P J Garvin; L Martis
Journal:  Toxicol Appl Pharmacol       Date:  1978-07       Impact factor: 4.219

3.  Effect of phthalic acid esters on gonadal function in male rats.

Authors:  S Oishi; K Hiraga
Journal:  Bull Environ Contam Toxicol       Date:  1979-01       Impact factor: 2.151

4.  Failure of monoethylhexyl phthalate to cause teratogenic effects in offspring of rabbits.

Authors:  J A Thomas; L G Schein; P K Gupta; R E McCafferty; P R Felice; M P Donovan
Journal:  Toxicol Appl Pharmacol       Date:  1979-12       Impact factor: 4.219

5.  Study of the testicular effects and changes in zinc excretion produced by some n-alkyl phthalates in the rat.

Authors:  P M Foster; L V Thomas; M W Cook; S D Gangolli
Journal:  Toxicol Appl Pharmacol       Date:  1980-07       Impact factor: 4.219

6.  Inhibition of androgen-receptor interaction in mouse prostate gland cytosol by divalent metal ions.

Authors:  M P Donovan; L G Schein; J A Thomas
Journal:  Mol Pharmacol       Date:  1980-03       Impact factor: 4.436

7.  Testicular atrophy induced by phthalic acid esters: effect on testosterone and zinc concentrations.

Authors:  S Oishi; K Hiraga
Journal:  Toxicol Appl Pharmacol       Date:  1980-03-30       Impact factor: 4.219

8.  Short-term toxicity study of di-(2-ethylhexyl) phthalate in rats.

Authors:  T J Gray; K R Butterworth; I F Gaunt; G P Grasso; S D Gangolli
Journal:  Food Cosmet Toxicol       Date:  1977-10

9.  Studies on the effects of orally administered Di-(2-ethylhexyl) phthalate in the ferret.

Authors:  B G Lake; P G Brantom; S D Gangolli; K R Butterworth; P Grasso
Journal:  Toxicology       Date:  1976 Nov-Dec       Impact factor: 4.221

10.  Effect of phthalic acid esters on mouse testes.

Authors:  S Oishi; K Hiraga
Journal:  Toxicol Lett       Date:  1980-05       Impact factor: 4.372
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  5 in total

1.  Rapid detection of DEHP in packed red blood cells stored under European and US standard conditions.

Authors:  Angelo D'alessandro; Travis Nemkov; Kirk C Hansen
Journal:  Blood Transfus       Date:  2015-11-27       Impact factor: 3.443

2.  Women's exposure to phthalates in relation to use of personal care products.

Authors:  Lauren E Parlett; Antonia M Calafat; Shanna H Swan
Journal:  J Expo Sci Environ Epidemiol       Date:  2012-11-21       Impact factor: 5.563

3.  Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles.

Authors:  Wei Wang; Zelieann R Craig; Mallikarjuna S Basavarajappa; Katlyn S Hafner; Jodi A Flaws
Journal:  Biol Reprod       Date:  2012-12-27       Impact factor: 4.285

4.  Effects of intravenous and oral di(2-ethylhexyl) phthalate (DEHP) and 20% Intralipid vehicle on neonatal rat testis, lung, liver, and kidney.

Authors:  Luísa Camacho; John R Latendresse; Levan Muskhelishvili; Charles D Law; K Barry Delclos
Journal:  Food Chem Toxicol       Date:  2020-06-13       Impact factor: 6.023

5.  The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay.

Authors:  Susan M Duty; Narendra P Singh; Manori J Silva; Dana B Barr; John W Brock; Louise Ryan; Robert F Herrick; David C Christiani; Russ Hauser
Journal:  Environ Health Perspect       Date:  2003-07       Impact factor: 9.031
  5 in total

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