Literature DB >> 7140549

[Chemotherapy schedule for the management of metastasizing gastric cancer. Methotrexate, adriamycin and 5-fluorouracil].

H O Klein, P D Wickramanayake, F Dieterle, R Mohr, H Oerkermann, J Brock, D Beyer, R Gross.   

Abstract

The possible effectiveness of methotrexate, 5-fluorouracil and adriamycin was tested in a phase I/II study of patients with metastasising gastric carcinoma. complete of partial remission occurred in 19 of 30 patients (approximately 63%). Two of 30 patients had complete remission. Median survival time of patients with remission cannot as yet be determined: about 68% are still alive after 17 months. Median survival time of patients with advanced tumour was only five months. The difference in survival curve is statistically significant (P less than 0.05). The study is continuing.

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Year:  1982        PMID: 7140549     DOI: 10.1055/s-2008-1070192

Source DB:  PubMed          Journal:  Dtsch Med Wochenschr        ISSN: 0012-0472            Impact factor:   0.628


  6 in total

1.  An EORTC gastrointestinal (GI) group randomized evaluation of the toxicity of sequential high dose methotrexate and 5-fluorouracil combined with adriamycin (FAMTX) vs 5-fluorouracil, adriamycin and mitomycin (FAM) in advanced gastric cancer.

Authors:  H O Klein; J Wils; H Bleiberg; M Buyse; N Duez
Journal:  Med Oncol Tumor Pharmacother       Date:  1989

Review 2.  Status of treatment for advanced gastric carcinoma.

Authors:  James Y Tsai; Howard Safran
Journal:  Curr Oncol Rep       Date:  2003-05       Impact factor: 5.075

3.  Sequential methotrexate (MTX) and 5-fluorouracil (FU) in human tumor xenografts.

Authors:  K Wayss; R Herrmann; J Mattern; M Volm
Journal:  Med Oncol Tumor Pharmacother       Date:  1985

4.  Combination chemotherapy of S-1 and low-dose cisplatin for advanced gastric cancer.

Authors:  Shunichi Tsujitani; Kenji Fukuda; Nobuaki Kaibara
Journal:  Gastric Cancer       Date:  2003       Impact factor: 7.370

Review 5.  Chemotherapy for gastric cancer.

Authors:  Javier Sastre; Jose Angel Garcia-Saenz; Eduardo Diaz-Rubio
Journal:  World J Gastroenterol       Date:  2006-01-14       Impact factor: 5.742

6.  Update in cancer chemotherapy: gastrointestinal cancer--colorectal cancer, Part 2.

Authors:  J C Wright
Journal:  J Natl Med Assoc       Date:  1986-05       Impact factor: 1.798

  6 in total

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