Literature DB >> 7140079

Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist.

I A Rosner, C J Malemud, V M Goldberg, R S Papay, L Getzy, R W Moskowitz.   

Abstract

Tamoxifen, an estradiol antagonist, and estradiol were separately evaluated in a rabbit experimental osteoarthritis. Cartilage from anatomically defined regions of individual rabbit knees was assayed for sulfate and thymidine incorporation. Tamoxifen reduced erosive osteoarthritic pathology, while estradiol worsened it. There was no effect on the incidence of osteophytes. Metabolic studies in organ culture showed no changes relating to treatment. The results suggest that specific medical therapy for osteoarthritis is within the realm of possibility.

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Year:  1982        PMID： 7140079

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN： 0009-921X            Impact factor:   4.176


  8 in total

Review 1.  Oestrogens, joint disease, and cartilage.

Authors:  C L Chander; T D Spector
Journal:  Ann Rheum Dis       Date:  1991-03       Impact factor: 19.103

Review 2.  Generalised osteoarthritis: a hormonally mediated disease.

Authors:  T D Spector; G D Campion
Journal:  Ann Rheum Dis       Date:  1989-06       Impact factor: 19.103

3.  Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes.

Authors:  Yun Jong Lee; Eun Bong Lee; Young Ee Kwon; Jung Jin Lee; Woo Shin Cho; Hyun A Kim; Yeong Wook Song
Journal:  Rheumatol Int       Date:  2003-04-09       Impact factor: 2.631

Review 4.  Obstetric and gynaecological factors in susceptibility to peripheral joint osteoarthritis.

Authors:  A J Silman; J Newman
Journal:  Ann Rheum Dis       Date:  1996-09       Impact factor: 19.103

Review 5.  Animal models for osteoarthritis: processes, problems and prospects.

Authors:  K P Pritzker
Journal:  Ann Rheum Dis       Date:  1994-06       Impact factor: 19.103

6.  Estradiol Inhibits ER Stress-Induced Apoptosis in Chondrocytes and Contributes to a Reduced Osteoarthritic Cartilage Degeneration in Female Mice.

Authors:  Rita Dreier; Thomas Ising; Markus Ramroth; Yvonne Rellmann
Journal:  Front Cell Dev Biol       Date:  2022-05-20

Review 7.  Are estrogen-related drugs new alternatives for the management of osteoarthritis?

Authors:  Ya-Ping Xiao; Fa-Ming Tian; Mu-Wei Dai; Wen-Ya Wang; Li-Tao Shao; Liu Zhang
Journal:  Arthritis Res Ther       Date:  2016-06-28       Impact factor: 5.156

8.  Estrogen deficiency accelerates lumbar facet joints arthritis.

Authors:  Hao Chen; Hai Zhu; Kai Zhang; Kangwu Chen; Huilin Yang
Journal:  Sci Rep       Date:  2017-05-03       Impact factor: 4.379
  8 in total

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