| Literature DB >> 7139327 |
M P Gilbey, J H Coote, S Fleetwood-Walker, D F Peterson.
Abstract
In anaesthetized rats the effect of two procedures was studied on antidromically identified sympathetic preganglionic neurones (SPN) in the second thoracic (T) segment of the spinal cord: the application of iontophoresed oxytocin and vasopressin, and bipolar electrical stimulation of the paraventricular nucleus of the hypothalamus (PVN). In the majority of cases (16/23) oxytocin inhibited SPN firing, 1/23 being excited. Vasopressin inhibited 8/14 neurones and excited 4/14. PVN stimulation inhibited SPN apparently by an action on the membrane of SPN. The possibility that oxytocin and vasopressin act as transmitters in the paraventriculo-spinal pathway, and their possible involvement in the mediation of PVN evoked inhibition of SPN activity has been discussed.Entities:
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Year: 1982 PMID： 7139327 DOI： 10.1016/0006-8993(82)90745-4
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252