Literature DB >> 7139118

Changes in phosphatidylinositol-4,5-bisphosphate 10 seconds after stimulation of washed rabbit platelets with ADP.

J D Vickers, R L Kinlough-Rathbone, J F Mustard.   

Abstract

Adenosine diphosphate (ADP) induced aggregation of rabbit platelets, without the release reaction, causes a significant decrease (7%) in the amount of phosphatidylinositol-4,5-bisphosphate (PIP2) at 10 sec and at 60 sec (11%). In platelets prelabeled with 32P-phosphate, this decrease in PIP2 is associated with a decrease in PIP2 radioactivity, which is significant at 50 sec. The decrease in PIP2 is sufficient to mobilize about 0.18 nmole Ca2+/10(9) platelets. In view of the key role played by Ca2+ in ADP-induced platelet shape change and aggregation, this evidence is compatible with the hypothesis that changes in PIP2 can be a source of calcium for cellular responses to agonists.

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Year:  1982        PMID： 7139118

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  11 in total

1.  Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots formed by thrombin.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

2.  Palmitic acid-labeled lipids selectively incorporated into platelet cytoskeleton during aggregation.

Authors:  M A Packham; M A Guccione; N L Bryant; A Livne
Journal:  Lipids       Date:  1990-07       Impact factor: 1.880

3.  Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets.

Authors:  C Lalau Keraly; J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

4.  The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

5.  The phosphoinositides exist in multiple metabolic pools in rabbit platelets.

Authors:  J D Vickers; J F Mustard
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857

6.  Breakdown of phosphatidylinositol 4,5-bisphosphate in a T-cell leukaemia line stimulated by phytohaemagglutinin is not dependent on Ca2+ mobilization.

Authors:  T Sasaki; H Hasegawa-Sasaki
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

7.  Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

8.  Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP.

Authors:  S E Rittenhouse
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

9.  Incorporation of lipids labeled with various fatty acids into the cytoskeleton of aggregating platelets.

Authors:  M A Packham; M A Guccione; N L Bryant; A Livne
Journal:  Lipids       Date:  1991-07       Impact factor: 1.880

10.  Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action.

Authors:  M J Rebecchi; M C Gershengorn
Journal:  Biochem J       Date:  1983-11-15       Impact factor: 3.857
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