Literature DB >> 7136786

The effect of nicotinic and muscarinic receptor blockade on cholera toxin induced intestinal secretion in rats and cats.

J Cassuto, M Jodal, O Lundgren.   

Abstract

The effects of hexamethonium (cholinergic nicotinic receptor antagonist) and atropine (cholinergic muscarinic receptor antagonist) on cholera toxin induced secretion were investigated in denervated segments of the small intestine of rats and cats. While there was no effect of atropine, hexamethonium markedly inhibited choleraic secretion and turned it into a net fluid absorption in many animals. This observation further strengthens our hypothesis that the enteric nervous system is involved in cholera secretion.

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Year:  1982        PMID： 7136786     DOI： 10.1111/j.1748-1716.1982.tb07026.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  18 in total

Review 1.  Enteric nervous system. I. Physiology and pathophysiology of the intestinal tract.

Authors:  O Lundgren; J Svanvik; L Jivegård
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

2.  Antisecretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist in human and rat small intestine.

Authors:  Matthew R Banks; Michael J G Farthing; Patrick Robberecht; David E Burleigh
Journal:  Br J Pharmacol       Date:  2005-04       Impact factor: 8.739

Review 3.  Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.

Authors:  C L Sears; J B Kaper
Journal:  Microbiol Rev       Date:  1996-03

Review 4.  Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition.

Authors:  Uday C Ghoshal; M Masudur Rahman
Journal:  Indian J Gastroenterol       Date:  2019-04

5.  Involvement of nerves and calcium channels in the intestinal response to Clostridium difficile toxin A: an experimental study in rats in vivo.

Authors:  J Sörensson; M Jodal; O Lundgren
Journal:  Gut       Date:  2001-07       Impact factor: 23.059

6.  Intraluminal bile salt increases rate of firing in afferent fibers from the small intestine of the rat.

Authors:  M H Tantisira; M Jodal; O Lundgren
Journal:  Experientia       Date:  1987-02-15

Review 7.  Cholera.

Authors:  J B Kaper; J G Morris; M M Levine
Journal:  Clin Microbiol Rev       Date:  1995-01       Impact factor: 26.132

8.  Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.

Authors:  N H Alam; H Ashraf; W A Khan; M M Karim; G J Fuchs
Journal:  Gut       Date:  2003-10       Impact factor: 23.059

9.  I, 3. The enteric nervous system and infectious diarrhea.

Authors:  Ove Lundgren; Lennart Svensson
Journal:  Perspect Med Virol       Date:  2004-09-14

10.  5-Hydroxytryptamine and cholera secretion: a histochemical and physiological study in cats.

Authors:  O Nilsson; J Cassuto; P A Larsson; M Jodal; P Lidberg; H Ahlman; A Dahlström; O Lundgren
Journal:  Gut       Date:  1983-06       Impact factor: 23.059
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