The effect of transistor-regulated direct current on non-fractured rabbit femur.

An experienced study was performed to examine the effects of transistor-regulated 20 microampère direct current on rabbit femur and to evaluate methods of measuring the effects. The anode and the cathode were both placed in drill holes in the anterior aspect of the cortex of the right femur, the left femur being used as a control with the electrodes without current. The effects of the electrical stimulation were evaluated by means of roentgenograms, photomorphometric measurements of the cortical width and measurements of bone volume, ash-weight and 85Sr uptake. In the roentgenograms it could be seen that osteogenesis was induced both at the anode and the cathode. Also, an increased uptake of 85Sr was demonstrated indicating an increased bone formation rate.