Literature DB >> 7135354

The kinetic mechanism of glutathione peroxidase from human platelets.

J I Martínez, R D García, A M Galarza.   

Abstract

Human platelet glutathione peroxidase (GSH-Px) exhibits a ping-pong type kinetic mechanism. Peroxide changes the redox state of the enzyme and renders it highly stable against attack by alkylating agents. Peroxide seems also to act as a positive homotropic modulator modifying the allosteric kinetics of the enzyme. The combination of these two mechanisms accelerates response against peroxides. This finding reassesses importance of GSH-Px for the platelet protection.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7135354     DOI： 10.1016/0049-3848(82)90199-2

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  7 in total

Review 1.  Redox regulation of mitochondrial function.

Authors:  Diane E Handy; Joseph Loscalzo
Journal:  Antioxid Redox Signal       Date:  2012-02-03       Impact factor: 8.401

2.  A mechanistic mathematical model for the catalytic action of glutathione peroxidase.

Authors:  V R Pannala; J N Bazil; A K S Camara; R K Dash
Journal:  Free Radic Res       Date:  2014-02-24

Review 3.  Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.

Authors:  Edith Lubos; Joseph Loscalzo; Diane E Handy
Journal:  Antioxid Redox Signal       Date:  2011-04-10       Impact factor: 8.401

4.  Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach.

Authors:  Tatiana A Karelina; Kirill V Zhudenkov; Oleg O Demin; Dmitry V Svetlichny; Balaji Agoram; David Fairman; Oleg V Demin
Journal:  BMC Syst Biol       Date:  2012-11-12

5.  Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments.

Authors:  Jeffrey M Stolwijk; Kelly C Falls-Hubert; Charles C Searby; Brett A Wagner; Garry R Buettner
Journal:  Redox Biol       Date:  2020-03-29       Impact factor: 11.799

6.  Differentially Expressed Hepatic Genes Revealed by Transcriptomics in Pigs with Different Liver Lipid Contents.

Authors:  Wentao Lyu; Yun Xiang; Xingxin Wang; Jingshang Li; Caimei Yang; Hua Yang; Yingping Xiao
Journal:  Oxid Med Cell Longev       Date:  2022-01-28       Impact factor: 6.543

Review 7.  Understanding the Redox Biology of Selenium in the Search of Targeted Cancer Therapies.

Authors:  Jeffrey M Stolwijk; Rohan Garje; Jessica C Sieren; Garry R Buettner; Yousef Zakharia
Journal:  Antioxidants (Basel)       Date:  2020-05-13
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.