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Literature DB >> 7134966

Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors.

Abstract

Old female rats with spontaneous prolactin-secreting pituitary tumors (prolactinomas) and young females with prolactinomas produced by prolonged estrogen treatment had damaged tuberoinfundibular dopaminergic neurons. Since these neurons inhibit the function of pituitary prolactin-secreting cells, their destruction may lead to development of prolactinomas.

Entities: Disease Species

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Year: 1982 PMID： 7134966 DOI： 10.1126/science.7134966

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

32 in total

Review 1. Angiotensin and calcium signaling in the pituitary and hypothalamus.

Authors: Cecilia Suárez; Isabel García Tornadú; Carolina Cristina; Jorge Vela; Arturo González Iglesias; Carlos Libertun; Graciela Díaz-Torga; Damasia Becu-Villalobos
Journal: Cell Mol Neurobiol Date: 2002-06 Impact factor: 5.046

2. Pituitary portal plasma levels of oxytocin during the estrous cycle, lactation, and hyperprolactinemia.

Authors: D K Sarkar; S A Frautschy; N Mitsugi
Journal: Ann N Y Acad Sci Date: 1992-06-12 Impact factor: 5.691

3. Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes.

Authors: D K Sarkar; K Chaturvedi; S Oomizu; N I Boyadjieva; C P Chen
Journal: Endocrinology Date: 2005-06-16 Impact factor: 4.736

4. Reduced number of natural killer cells in patients with pathological hyperprolactinemia.

Authors: R Gerli; P Rambotti; I Nicoletti; S Orlandi; G Migliorati; C Riccardi
Journal: Clin Exp Immunol Date: 1986-05 Impact factor: 4.330

Review 5. The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis.

Authors: D D Rasmussen
Journal: J Endocrinol Invest Date: 1991-04 Impact factor: 4.256

10. Distribution of 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylglycol (DOPEG) in microdissected brain structures and the pituitary gland: metabolite changes in the median eminence in response to hyperprolactinemia and suckling.

Authors: J I Mechanick; I R Cohen-Becker; K A Gregerson; M Selmanoff
Journal: J Neural Transm Date: 1987 Impact factor: 3.575

Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors.

Review 1. Angiotensin and calcium signaling in the pituitary and hypothalamus.

2. Pituitary portal plasma levels of oxytocin during the estrous cycle, lactation, and hyperprolactinemia.

3. Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes.

4. Reduced number of natural killer cells in patients with pathological hyperprolactinemia.

Review 5. The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis.

6. Estrogen inhibits tuberoinfundibular dopaminergic neurons but does not cause irreversible damage.

Review 7. Growth factors in the pathogenesis of prolactin-secreting tumors.

8. Nerve growth factor, D2 receptor isoforms, and pituitary tumors.

Review 9. Genesis of prolactinomas: studies using estrogen-treated animals.

10. Distribution of 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylglycol (DOPEG) in microdissected brain structures and the pituitary gland: metabolite changes in the median eminence in response to hyperprolactinemia and suckling.