Comparison of the antigenicity and tolerance of an influenza aluminium oxide adsorbate vaccine with an aqueous vaccine.

A randomized trial was carried out in 189 adult subjects to test the antigenicity and tolerance of two experimental influenza vaccines, one adsorbed onto aluminium oxide and the other one aqueous, with equal antigen contents. Blood samples for antibody assays, using the haemagglutination inhibition test and the neuraminidase inhibition test, were taken before and 30, 90 and 180 days after vaccination. The results showed that the adsorbate influenza vaccine had a superior immunogenic action to the aqueous vaccine at the same dose rate. There were no significant differences between the tolerances of the two vaccines, which were injected with a needle. About 81% of the vaccinated subjects showed no subjective or objective signs of intolerance. Systemic reactions, which were reported by 9% of the vaccinated subjects, were verified by the doctor in only 2% of cases.

RCT Entities:   Population Interventions Outcomes