Literature DB >> 7133157

Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.

H Abe, M Sakaguchi, S Odashima, S Arichi.   

Abstract

The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were studied in rats. Pretreatment with saikosaponin-d produced a remarkable inhibitory action on acute hepatic injury by CCl4. A significant inhibition of lipid peroxidation induced by an acute dose of CCl4 in the liver of rats pre-treated with saikosaponin-d was also noted. Continuous injection of CCl4 caused liver cirrhosis in rats but the severity of cirrhosis was reduced in rats treated simultaneously with CCl4 and saikosaponin-d.

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Year:  1982        PMID： 7133157     DOI： 10.1007/bf00510139

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

1.  Saponins isolated from Bupleurum falcatum L.; components of saikosaponin b.

Authors:  A Shimaoka; S Seo; H Minato
Journal:  J Chem Soc Perkin 1       Date:  1975

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Studies on the role of protein syntheis in cell injury by toxic agents: I. Effect of cycloheximide administration on several factors modulating carbon tetrachloride-induced liver necrosis.

Authors:  J A Castro; E C Ferreyra; C R de Castro; O M de Fenos; M I Diaz Gómez; T E Gram; R L Reagan; A M Guarino
Journal:  Toxicol Appl Pharmacol       Date:  1977-08       Impact factor: 4.219

4.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

Authors:  H Ohkawa; N Ohishi; K Yagi
Journal:  Anal Biochem       Date:  1979-06       Impact factor: 3.365

Review 5.  Carbon tetrachloride hepatotoxicity.

Authors:  R O Recknagel
Journal:  Pharmacol Rev       Date:  1967-06       Impact factor: 25.468

6.  [Pharmacological studies on Bupleurum falcatum L. II. Antiinflammatory and other pharmacological actions of crude saikosides].

Authors:  K Takagi; M Shibata
Journal:  Yakugaku Zasshi       Date:  1969-10       Impact factor: 0.302

7.  Pharmacological actions of saikosaponins isolated from Bupleurum falcatum. 1. Effects of saikosaponins on liver function.

Authors:  H Abe; M Sakaguchi; M Yamada; S Arichi; S Odashima
Journal:  Planta Med       Date:  1980-12       Impact factor: 3.352

8.  Modification of the hepatotoxicity of D-galactosamine in the rat by cycloheximide.

Authors:  R S Koff; L J Connelly
Journal:  Proc Soc Exp Biol Med       Date:  1976-03

9.  Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation.

Authors:  T F Slater
Journal:  Nature       Date:  1966-01-01       Impact factor: 49.962

10.  Erythrocyte membrane stabilization by plant saponins and sapogenins.

Authors:  H Abe; M Sakaguchi; M Anno; S Arichi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-06       Impact factor: 3.000
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  9 in total

1.  A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis.

Authors:  C Hirayama; M Okumura; K Tanikawa; M Yano; M Mizuta; N Ogawa
Journal:  Gastroenterol Jpn       Date:  1989-12

2.  Effects of saikosaponins on hepatic damage induced by halothane and hypoxia in phenobarbital-pretreated rats.

Authors:  Teruhiro Nishiura; Seishiro Marukawa; Hiroatsu Ishida; Machiko Orita; Hiroko Abe
Journal:  J Anesth       Date:  1994-03       Impact factor: 2.078

3.  Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.

Authors:  Mingzi Ouyang; Yanyan Liu; Wei Tan; Ya Xiao; Keqiang Yu; Xiaomin Sun; Ying Huang; JingRu Cheng; Ren Luo; Xiaoshan Zhao
Journal:  BMC Complement Altern Med       Date:  2014-12-15       Impact factor: 3.659

Review 4.  Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology.

Authors:  Fude Yang; Xiaoxv Dong; Xingbin Yin; Wenping Wang; Longtai You; Jian Ni
Journal:  Biomed Res Int       Date:  2017-05-16       Impact factor: 3.411

Review 5.  The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases.

Authors:  Byeong Mo Kim
Journal:  Oxid Med Cell Longev       Date:  2018-04-12       Impact factor: 6.543

Review 6.  Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action.

Authors:  Mohamed L Ashour; Michael Wink
Journal:  J Pharm Pharmacol       Date:  2010-11-16       Impact factor: 3.765

7.  Systematic Characterization and Identification of Saikosaponins in Extracts From Bupleurum marginatum var. stenophyllum Using UPLC-PDA-Q/TOF-MS.

Authors:  Wenxi Liu; Xianlong Cheng; Rong Kang; Yadan Wang; Xiaohan Guo; Wenguang Jing; Feng Wei; Shuangcheng Ma
Journal:  Front Chem       Date:  2021-09-30       Impact factor: 5.545

8.  Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats.

Authors:  Seong-Mo Kim; Sang-Chan Kim; In-Kwon Chung; Woo-Hyun Cheon; Sae-Kwang Ku
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-25       Impact factor: 2.629

9.  Mouse single oral dose toxicity test of bupleuri radix aqueous extracts.

Authors:  Kyung-Hu Kim; Cheol-Ou Gam; Seong-Hun Choi; Sae-Kwang Ku
Journal:  Toxicol Res       Date:  2012-03
  9 in total

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