On the choice of subject populations for research in neurobehavioral toxicology.

The choice of experimental subjects for research in neurobehavioral toxicology influences the questions that may be asked and the generality of findings obtained. In particular, the relative merits of "random bred" animals, heterogeneous stocks, selected lines, and inbred strains are discussed. Several aspects of genetic-environmental coaction that may influence data are described, and general issues for their analyses discussed.