Literature DB >> 7131488

Antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. A highly effective series of blood and tissue schizonticidal agents.

M P LaMontagne, P Blumbergs, R E Strube.   

Abstract

A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. The compounds were tested for suppressive activity against Plasmodium berghei in mice and for radical curative activity against Plasmodium cynomolgi in the rhesus monkey. The compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents.

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Year:  1982        PMID： 7131488     DOI： 10.1021/jm00351a017

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  11 in total

1.  2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.

Authors:  Nguyen Tien Huy; Keisuke Mizunuma; Kirandeep Kaur; Nguyen Thanh Thuy Nhien; Meenakshi Jain; Dinh Thanh Uyen; Shigeharu Harada; Rahul Jain; Kaeko Kamei
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

Review 2.  8-Aminoquinoline Therapy for Latent Malaria.

Authors:  J Kevin Baird
Journal:  Clin Microbiol Rev       Date:  2019-07-31       Impact factor: 26.132

Review 3.  New insight-guided approaches to detect, cure, prevent and eliminate malaria.

Authors:  Sushil Kumar; Renu Kumari; Richa Pandey
Journal:  Protoplasma       Date:  2014-10-17       Impact factor: 3.356

4.  Synthesis and anti-breast cancer activities of substituted quinolines.

Authors:  Aibin Shi; Thu A Nguyen; Srinivas K Battina; Sandeep Rana; Dolores J Takemoto; Peter K Chiang; Duy H Hua
Journal:  Bioorg Med Chem Lett       Date:  2008-04-13       Impact factor: 2.823

5.  Protection of retinal cells from ischemia by a novel gap junction inhibitor.

Authors:  Satyabrata Das; Dingbo Lin; Snehalata Jena; Aibin Shi; Srinivas Battina; Duy H Hua; Rachel Allbaugh; Dolores J Takemoto
Journal:  Biochem Biophys Res Commun       Date:  2008-06-30       Impact factor: 3.575

6.  Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.

Authors:  N P Dhammika Nanayakkara; Arba L Ager; Marilyn S Bartlett; Vanessa Yardley; Simon L Croft; Ikhlas A Khan; James D McChesney; Larry A Walker
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191

7.  Synthesis and evaluation of naphthyridine compounds as antimalarial agents.

Authors:  Shuren Zhu; Quan Zhang; Chandrashekar Gudise; Li Meng; Lai Wei; Erika Smith; Yuliang Kong
Journal:  Bioorg Med Chem Lett       Date:  2007-09-15       Impact factor: 2.823

8.  Fungal metabolism of 4-methylprimaquine.

Authors:  A M Clark; J D McChesney; C D Hufford
Journal:  Pharm Res       Date:  1986-06       Impact factor: 4.200

9.  Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.

Authors:  Anna Caroline C Aguiar; Flávio Jr B Figueiredo; Patrícia D Neuenfeldt; Tony H Katsuragawa; Bruna B Drawanz; Wilson Cunico; Photini Sinnis; Fidel Zavala; Antoniana U Krettli
Journal:  Malar J       Date:  2017-03-09       Impact factor: 2.979

10.  KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.

Authors:  Anne-Marie Zeeman; Sandra M van Amsterdam; Case W McNamara; Annemarie Voorberg-van der Wel; Els J Klooster; Alexander van den Berg; Edmond J Remarque; David M Plouffe; Geert-Jan van Gemert; Adrian Luty; Robert Sauerwein; Kerstin Gagaring; Rachel Borboa; Zhong Chen; Kelli Kuhen; Richard J Glynne; Arnab K Chatterjee; Advait Nagle; Jason Roland; Elizabeth A Winzeler; Didier Leroy; Brice Campo; Thierry T Diagana; Bryan K S Yeung; Alan W Thomas; Clemens H M Kocken
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191
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