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Literature DB >> 7129423

Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family.

G Bruun-Petersen, L U Lamm, B K Jacobsen, T Kristensen.

Abstract

A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB*35, Bf*F, and HLAD/DR*1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(A+) variant.

Entities: Gene

Mesh：

Substances：
Complement C4

Year: 1982 PMID： 7129423 DOI： 10.1007/bf00291328

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

8 in total

1. Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6.

Authors: P Teisberg; I Akesson; B Olaisen; T Gedde-Dahl; E Thorsby
Journal: Nature Date: 1976-11-18 Impact factor: 49.962

2. Two HLA-linked loci controlling the fourth component of human complement.

Authors: G J O'Neill; S Y Yang; B Dupont
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

3. Human complement C4 locus is duplicated on some chromosomes.

Authors: B Olaisen; P Teisberg; R Nordhagen; T Michaelsen; T Gedde-Dahl
Journal: Nature Date: 1979-06-21 Impact factor: 49.962

4. Chido and Rodgers blood groups are distinct antigenic components of human complement C4.

Authors: G J O'Neill; S Y Yang; J Tegoli; R Berger; B Dupont
Journal: Nature Date: 1978-06-22 Impact factor: 49.962

5. Family studies of complement C4 and HLA in man.

Authors: G Bruun-Petersen; L U Lamm; I J Sørensen; L Buskjaer; J P Mortensen
Journal: Hum Genet Date: 1981 Impact factor: 4.132

6. C4 haplotype products and partial inhibition of anti-Rodgers sera.

Authors: R Nordhagen; B Olaisen; P Teisberg; T Gedde-Dahl; E Thorsby
Journal: J Immunogenet Date: 1981-12

7. Inherited structural polymorphism of the fourth component of human complement.

Authors: Z L Awdeh; C A Alper
Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205

8. The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.

Authors: P Teisberg; B Olaisen; R Jonassen; T Gedde-Dahl; E Thorsby
Journal: J Exp Med Date: 1977-11-01 Impact factor: 14.307

8 in total

7 in total

1. Analysis of HLA-B35 variants and B35 haplotypes by isoelectric focusing and Southern blot analysis.

Authors: E Lederer; E Nössner; R Wank; D J Schendel
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

2. Quantitative variation of C4 variant proteins associated with many MHC haplotypes.

Authors: L Truedsson; Z Awdeh; E J Yunis; S Mrose; B Moore; C A Alper
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

3. Haplotype study on C4 polymorphism in Japanese. Associations with MHC alleles, complotypes, and HLA-complement haplotypes.

Authors: K Tokunaga; K Omoto; T Akaza; N Akiyama; H Amemiya; S Naito; T Sasazuki; H Satoh; T Juji
Journal: Immunogenetics Date: 1985 Impact factor: 2.846