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Literature DB >> 7129014

The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.

H Fujiki, M Suganuma, M Nakayasu, H Hoshino, R E Moore, T Sugimura.

Abstract

Aplysiatoxin is a new class of potent tumor promoter and debromoaplysiatoxin may be a weak promoter. Aplysiatoxin and debromoaplysiatoxin showed the same potency on irritation of mouse ear and induction of ornithine decarboxylase activity on mouse skin, but debromoaplysiatoxin was much weaker than aplysiatoxin in induction of adhesion of HL-60 cells.

Entities: Chemical Disease Gene Species

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Year: 1982 PMID： 7129014

Source DB: PubMed Journal: Gan ISSN： 0016-450X

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Cited

11 in total

1. Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is alpha 1-acid glycoprotein.

Authors: H Ueyama; I Sasaki; K Shimomura; M Suganuma
Journal: J Cancer Res Clin Oncol Date: 1995 Impact factor: 4.553

2. Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells.

Authors: J C Willey; C E Moser; C C Harris
Journal: Cell Biol Toxicol Date: 1984-10 Impact factor: 6.691

3. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

Authors: B Friedman; A R Frackelton; A H Ross; J M Connors; H Fujiki; T Sugimura; M R Rosner
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

4. A receptor model for tumor promoters: rational superposition of teleocidins and phorbol esters.

Authors: A Itai; Y Kato; N Tomioka; Y Iitaka; Y Endo; M Hasegawa; K Shudo; H Fujiki; S Sakai
Journal: Proc Natl Acad Sci U S A Date: 1988-06 Impact factor: 11.205

5. Effect of biological toxins on gap-junctional intercellular communication in Chinese hamster V79 cells.

Authors: C Jone; L Erickson; J E Trosko; C C Chang
Journal: Cell Biol Toxicol Date: 1987-03 Impact factor: 6.691

6. Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages.

Authors: K Ohuchi; T Sugawara; M Watanabe; N Hirasawa; S Tsurufuji; H Fujiki; S B Christensen; T Sugimura
Journal: Br J Pharmacol Date: 1988-07 Impact factor: 8.739

The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.

1. Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is alpha 1-acid glycoprotein.

2. Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells.

3. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

4. A receptor model for tumor promoters: rational superposition of teleocidins and phorbol esters.

5. Effect of biological toxins on gap-junctional intercellular communication in Chinese hamster V79 cells.

6. Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages.

Review 7. PKC in Regenerative Therapy: New Insights for Old Targets.

8. Oscillatoxin I: A New Aplysiatoxin Derivative, from a Marine Cyanobacterium.

9. New classes of environmental tumor promoters: indole alkaloids and polyacetates.

Review 10. Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies.