Literature DB >> 7128909

Effects of pentoxifylline on cell shape, ATP content and deformability in rabbit erythrocytes under hyperosmolar conditions.

T Nishio, Y Toshima, Y Matsuno.   

Abstract

1. Pentoxifylline (I) [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] (0-10(-3) M) inhibited the discocyte echinocyte transformation caused by hyperosmolarity and improved the impaired filtrability of erythrocytes due to hyperosmolarity. 2. The ATP content of erythrocytes was increased at low concentrations (0-3 x 10(-5) M) of I, but decreased at high concentrations (3 x 10(-5) M or above) of I.

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Year:  1982        PMID: 7128909     DOI: 10.1016/0020-711x(82)90075-1

Source DB:  PubMed          Journal:  Int J Biochem        ISSN: 0020-711X


  4 in total

1.  Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia.

Authors:  K Aihara; H Azuma; Y Ikeda; M Akaike; M Abe; T Sugihara; T Matsumoto
Journal:  Int J Hematol       Date:  2001-04       Impact factor: 2.490

Review 2.  Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.

Authors:  A Ward; S P Clissold
Journal:  Drugs       Date:  1987-07       Impact factor: 9.546

3.  Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia.

Authors:  W Gallenkämper; W Rücker; K Schrör
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739

4.  The effect of denbufylline on the viscosity of rat whole blood and on the deformability (filterability) of rat blood cell suspensions.

Authors:  J J Jukna; C D Nicholson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-04       Impact factor: 3.000

  4 in total

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