Literature DB >> 7128680

Interactions of [3H]LSD with serotonin receptors in human brain.

A J Cross.   

Abstract

The binding of [3H]LSD to serotonergic sites in human brain was studied. The pharmacological profile of [3H]LSD binding in frontal cortex differed to that in hippocampus. Analysis of the inhibition of [3H]LSD binding by serotonin and spiperone was consistent with the presence of two binding sites, which differed in pharmacological specificity. The results are discussed in relation to previously published findings in experimental animals.

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Year:  1982        PMID: 7128680     DOI: 10.1016/0014-2999(82)90555-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  2 in total

Review 1.  Human platelet 5-hydroxytryptamine receptors: binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration.

Authors:  D G Grahame-Smith; D P Geaney; M Schachter; J M Elliott
Journal:  Experientia       Date:  1988-02-15

2.  High affinity serotonin binding sites in human brain: a comparison of cerebral cortex and basal ganglia.

Authors:  A J Cross; P Slater
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

  2 in total

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