Literature DB >> 7126766

Determination of formaldehyde in biological tissues by gas chromatography/mass spectrometry.

H D Heck, E L White, M Casanova-Schmitz.   

Abstract

A quantitative method is described for the determination of formaldehyde in biological tissues by stable isotope dilution using gas chromatography/mass spectrometry. (13C2H2)Formaldehyde is used as the isotopic diluent. After tissue homogenization, derivatization is carried out in situ with pentafluorophenylhydrazine, followed by extraction and analysis using selected ion monitoring. The sensitivity of the technique is higher than that of conventional methods of formaldehyde analysis, enabling endogenous formaldehyde to be quantitatively analyzed in tissues, even in samples as small as 20 mg wet weight. The effects of exposure to airborne formaldehyde or to airborne methyl chloride on the formaldehyde concentrations of several tissues of Fischer-344 rats are reported.

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Year:  1982        PMID： 7126766     DOI： 10.1002/bms.1200090808

Source DB:  PubMed          Journal:  Biomed Mass Spectrom        ISSN： 0306-042X


  24 in total

1.  Biochemical effects of methyl chloride in relation to its tumorigenicity.

Authors:  R Jäger; H Peter; W Sterzel; H M Bolt
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

2.  Accumulated hippocampal formaldehyde induces age-dependent memory decline.

Authors:  Zhiqian Tong; Chanshuai Han; Wenhong Luo; Xiaohui Wang; Hui Li; Hongjun Luo; Jiangning Zhou; Jinshun Qi; Rongqiao He
Journal:  Age (Dordr)       Date:  2012-03-03

3.  Toxicokinetics and molecular interaction of [14C]-formaldehyde in rats.

Authors:  R K Upreti; M Y Farooqui; A E Ahmed; G A Ansari
Journal:  Arch Environ Contam Toxicol       Date:  1987-05       Impact factor: 2.804

Review 4.  DNA-protein crosslink formation by endogenous aldehydes and AP sites.

Authors:  Jun Nakamura; Mai Nakamura
Journal:  DNA Repair (Amst)       Date:  2020-02-10

5.  Measurement of Endogenous versus Exogenous Formaldehyde-Induced DNA-Protein Crosslinks in Animal Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry.

Authors:  Yongquan Lai; Rui Yu; Hadley J Hartwell; Benjamin C Moeller; Wanda M Bodnar; James A Swenberg
Journal:  Cancer Res       Date:  2016-03-16       Impact factor: 12.701

6.  Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis.

Authors:  Lajos Trézl; Lehel Hullán; Zsuzsa M Jászay; Tibor Szarvas; Imre Petneházy; Béla Szende; József Bocsi; Zoltán Takáts; Károly Vékey; László Töke
Journal:  Mol Cell Biochem       Date:  2003-02       Impact factor: 3.396

7.  Formation of S-[1-(N2-deoxyguanosinyl)methyl]glutathione between glutathione and DNA induced by formaldehyde.

Authors:  Kun Lu; Wenjie Ye; Avram Gold; Louise M Ball; James A Swenberg
Journal:  J Am Chem Soc       Date:  2009-03-18       Impact factor: 15.419

Review 8.  Redox Signaling by Reactive Electrophiles and Oxidants.

Authors:  Saba Parvez; Marcus J C Long; Jesse R Poganik; Yimon Aye
Journal:  Chem Rev       Date:  2018-08-27       Impact factor: 60.622

9.  Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders.

Authors:  Eun-Sook Lee; Hongtao Chen; Chadwick Hardman; Anthony Simm; Clivel Charlton
Journal:  Life Sci       Date:  2008-10-05       Impact factor: 5.037

10.  Postoperative cognitive dysfunction is correlated with urine formaldehyde in elderly noncardiac surgical patients.

Authors:  Jiawan Wang; Tao Su; Ying Liu; Yun Yue; Rongqiao He
Journal:  Neurochem Res       Date:  2012-08-07       Impact factor: 3.996
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