Literature DB >> 7126420

Alteration of plasma prednisolone levels by indomethacin and naproxen.

S A Rae, I A Williams, J English, E M Baylis.   

Abstract

Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P less than 0.001) increase in free prednisolone levels after concurrent therapy with either indomethacin or naproxen for 2 weeks. Total prednisolone levels were unchanged. These results could provide an explanation for clinical reports that these two NSAI drugs possess a steroid-sparing effect.

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Year:  1982        PMID： 7126420      PMCID： PMC1427625          DOI： 10.1111/j.1365-2125.1982.tb02010.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  10 in total

1.  Variation in plasma prednisolone concentrations in renal transplant recipients given enteric-coated prednisolone.

Authors:  R G Henderson; T Wheatley; J English; J Chakraborty; V Marks
Journal:  Br Med J       Date:  1979-06-09

2.  The effect of anti-inflammatory drugs on the protein-binding of 11-hydroxysteroids in human plasma in vitro.

Authors:  J B Stenlake; W D Williams; A G Davidson; W Downie; K Whaley
Journal:  J Pharm Pharmacol       Date:  1969-07       Impact factor: 3.765

3.  Prednisone side-effects and serum-protein levels. A collaborative study.

Authors:  G P Lewis; W J Jusko; L Graves; C W Burke
Journal:  Lancet       Date:  1971-10-09       Impact factor: 79.321

4.  Drug therapy. Serum drug concentrations as therapeutic guides.

Authors:  J Koch-Weser
Journal:  N Engl J Med       Date:  1972-08-03       Impact factor: 91.245

5.  Therapeutic value of indomethacin. (A review and clinical study).

Authors:  G F Morkel
Journal:  Curr Ther Res Clin Exp       Date:  1966-04

6.  Displacement of one drug by another from carrier or receptor sites.

Authors:  B B Brodie
Journal:  Proc R Soc Med       Date:  1965-11

7.  Naproxen: corticosteroid-sparing effect in rheumatoid arthritis.

Authors:  J J Badia Flores; S Valdez Rojas
Journal:  J Clin Pharmacol       Date:  1975-04       Impact factor: 3.126

8.  An extended study of indomethacin. II. Clinical therapy.

Authors:  N O Rothermich
Journal:  JAMA       Date:  1966-03-28       Impact factor: 56.272

9.  [Steroid saving effect of naproxen].

Authors:  H Mathies
Journal:  Arzneimittelforschung       Date:  1975-02

10.  Prednisolone absorption in acute colitis.

Authors:  P R Elliott; J Powell-Tuck; P E Gillespie; J M Laidlow; J E Lennard-Jones; J English; J Chakraborty; V Marks
Journal:  Gut       Date:  1980-01       Impact factor: 23.059
  10 in total
  3 in total

Review 1.  Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs.

Authors:  R K Verbeeck
Journal:  Clin Pharmacokinet       Date:  1990-07       Impact factor: 6.447

Review 2.  Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation.

Authors:  Troels K Bergmann; Katherine A Barraclough; Katie J Lee; Christine E Staatz
Journal:  Clin Pharmacokinet       Date:  2012-11       Impact factor: 6.447

Review 3.  Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data.

Authors:  J A P Da Silva; J W G Jacobs; J R Kirwan; M Boers; K G Saag; L B S Inês; E J P de Koning; F Buttgereit; M Cutolo; H Capell; R Rau; J W J Bijlsma
Journal:  Ann Rheum Dis       Date:  2005-08-17       Impact factor: 19.103
  3 in total

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