Literature DB >> 7126245

A new specific inhibitor of monoamine oxidase A.

C H Williams.   

Abstract

A new propynylamine has been tested as an inhibitor of MAO. Loosely based upon the structure of clorgyline, it is an irreversible inhibitor of MAO A but is apparently indifferent towards MAO B. This compound, N1-(2,4-dinitrophenyl)-N2-prop-2-ynyl 1,3-diaminopropane, may be useful as a model for the design of more potent but equally specific inhibitors of MAO A.

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Year:  1982        PMID: 7126245     DOI: 10.1016/0006-2952(82)90121-6

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN: 0006-2952            Impact factor:   5.858


  2 in total

1.  Mechanism-based inhibition of monoamine oxidase by 3-aryl-Delta3-pyrrolines.

Authors:  C H Williams; J Lawson
Journal:  Biochem J       Date:  1998-11-15       Impact factor: 3.857

2.  Oxidation of 3-amino-1-phenylprop-1-enes by monoamine oxidase and their use in a continuous assay of the enzyme.

Authors:  C H Williams; J Lawson; F R Backwell
Journal:  Biochem J       Date:  1988-12-15       Impact factor: 3.857

  2 in total

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