Literature DB >> 7125911

In vivo biotransformation and biliary excretion of 1-14C-acrylonitrile in rats.

B I Ghanayem, A E Ahmed.   

Abstract

1-14C-Acrylonitrile (VCN) was give orally to rats, 27% of the given dose was excreted in bile in 6 h. When 1-14C-VCN was given to overnight fasted or cobaltous chloride treated rats, a significant increase in the biliary excretion occurred. Pretreatment of rats with phenobarbital produced no change, while diethyl maleate pretreatment significantly decreased the portion of the dose excreted in bile in 6 h. Four metabolites of 1-14C-VCN have been isolated from the collected bile, and characterized. The two major biliary metabolites were found to be glutathione (GSH) conjugates of VCN, indicating the importance of GSH in VCN biotransformation.

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Year:  1982        PMID： 7125911     DOI： 10.1007/bf00373400

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  16 in total

1.  Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

Authors:  R H KNIGHT; L YOUNG
Journal:  Biochem J       Date:  1958-09       Impact factor: 3.857

2.  Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions.

Authors:  S Szabo; K A Bailey; P J Boor; R J Jaeger
Journal:  Biochem Biophys Res Commun       Date:  1977-11-07       Impact factor: 3.575

3.  A new acid hydrolysis method for determining tryptophan in peptides and proteins.

Authors:  B Penke; R Ferenczi; K Kovács
Journal:  Anal Biochem       Date:  1974-07       Impact factor: 3.365

4.  Enzymes catalysing conjugations of glutathione with alpha-beta-unsaturated carbonyl compounds.

Authors:  E Boyland; L F Chasseaud
Journal:  Biochem J       Date:  1968-10       Impact factor: 3.857

5.  Secondary metabolism of benzo(a)pyrene in human cells.

Authors:  E T Cantrell; M Marshall; T McLemore; B Ghanayem; D Busbee
Journal:  Proc West Pharmacol Soc       Date:  1979

6.  Teratogenicity of acrylonitrile given to rats by gavage or by inhalation.

Authors:  F J Murray; B A Schwetz; K D Nitschke; J A John; J M Norris; P J Gehring
Journal:  Food Cosmet Toxicol       Date:  1978-12

7.  Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion.

Authors:  C Maltoni; A Ciliberti; V Di Maio
Journal:  Med Lav       Date:  1977 Nov-Dec       Impact factor: 1.275

8.  Enzyme-catalysed conjugations of glutathione with unsaturated compounds.

Authors:  E Boyland; L F Chasseaud
Journal:  Biochem J       Date:  1967-07       Impact factor: 3.857

9.  Identification of the major urinary metabolites of acrylonitrile in the rat.

Authors:  P W Langvardt; C L Putzig; W H Braun; J D Young
Journal:  J Toxicol Environ Health       Date:  1980-03

10.  Metabolism of acrylonitrile to cyanide. In vitro studies.

Authors:  M E Abreu; A E Ahmed
Journal:  Drug Metab Dispos       Date:  1980 Nov-Dec       Impact factor: 3.922
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  2 in total

1.  Modulation of acrylonitrile-induced embryotoxicity in vitro by glutathione depletion.

Authors:  A M Saillenfait; J P Payan; I Langonné; D Beydon; M C Grandclaude; J P Sabaté; J de Ceaurriz
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

2.  Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats.

Authors:  L T Burka; I M Sanchez; A E Ahmed; B I Ghanayem
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153
  2 in total

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