Literature DB >> 7121213

Antioxidant activities of tocopherols on Fe2+-ascorbate-induced lipid peroxidation in lecithin liposomes.

K Fukuzawa, A Tokumura, S Ouchi, H Tsukatani.   

Abstract

The antioxidant activities of 4 tocopherols, tocol, and a water-soluble model analog of alpha-tocopherol were compared. Egg lecithin liposomes were used and oxidation was catalyzed by Fe2+-ascorbate. The activities decreased in the order alpha greater than beta greater than gamma greater than delta-tocopherol greater than tocol, in agreement with their potencies in vivo. The water-soluble analog was the least effective. Activity depended on the molar ratio of antioxidant to unsaturated lipid, with one molecule each of the alpha-, beta-, gamma-, delta-tocopherol and tocol capable of protecting, respectively, 220, 120, 100, 30 and 20 molecules of polyunsaturated fatty acid. The mechanism of possible antioxidant effect of the compounds used is discussed.

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Year:  1982        PMID： 7121213     DOI： 10.1007/bf02535334

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  10 in total

1.  delta-Tocopherol; isolation from soybean oil and properties.

Authors:  M H STERN; C D ROBESON
Journal:  J Am Chem Soc       Date:  1947-04       Impact factor: 15.419

2.  A simplified purification of lecithin.

Authors:  M C PANGBORN
Journal:  J Biol Chem       Date:  1951-02       Impact factor: 5.157

Review 3.  Vitamin E and free radical peroxidation of lipids.

Authors:  A L Tappel
Journal:  Ann N Y Acad Sci       Date:  1972-12-18       Impact factor: 5.691

4.  Determination of lipid phosphorus in the nanomolar range.

Authors:  A Chalvardjian; E Rudnicki
Journal:  Anal Biochem       Date:  1970-07       Impact factor: 3.365

5.  Vitamin E protection of membrane lipids during electron transport functions.

Authors:  P B McCay; P M Pfeifer; W H Stipe
Journal:  Ann N Y Acad Sci       Date:  1972-12-18       Impact factor: 5.691

6.  Antioxidative effect of alpha-tocopherol incorporation into lecithin liposomes on ascorbic acid-Fe2+-induced lipid peroxidation.

Authors:  K Fukuzawa; H Chida; A Tokumura; H Tsukatani
Journal:  Arch Biochem Biophys       Date:  1981-01       Impact factor: 4.013

7.  Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. I. Cupric and ferric ion catalyzed oxidation.

Authors:  M M Khan; A E Martell
Journal:  J Am Chem Soc       Date:  1967-08-02       Impact factor: 15.419

8.  Superoxide dependent lipid peroxidation.

Authors:  M Tien; B A Svingen; S D Aust
Journal:  Fed Proc       Date:  1981-02

9.  Lipid peroxidation in vivo during vitamin E and selenium deficiency in the rat as monitored by ethane evolution.

Authors:  D G Hafeman; W G Hoekstra
Journal:  J Nutr       Date:  1977-04       Impact factor: 4.798

10.  Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content.

Authors:  D J Kornbrust; R D Mavis
Journal:  Lipids       Date:  1980-05       Impact factor: 1.880
  10 in total
  15 in total

1.  Nonenzymatic lipid peroxidation reprograms gene expression and activates defense markers in Arabidopsis tocopherol-deficient mutants.

Authors:  Scott E Sattler; Laurent Mène-Saffrané; Edward E Farmer; Markus Krischke; Martin J Mueller; Dean DellaPenna
Journal:  Plant Cell       Date:  2006-12-28       Impact factor: 11.277

Review 2.  RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses.

Authors:  Jordan M Chapman; Joëlle K Muhlemann; Sheena R Gayomba; Gloria K Muday
Journal:  Chem Res Toxicol       Date:  2019-03-11       Impact factor: 3.739

3.  Characterization of an Arabidopsis mutant deficient in gamma-tocopherol methyltransferase.

Authors:  Eveline Bergmüller; Svetlana Porfirova; Peter Dörmann
Journal:  Plant Mol Biol       Date:  2003-08       Impact factor: 4.076

4.  Oxidative stability of oil-in-water emulsions with α-tocopherol, charged emulsifier, and different oxidative stress.

Authors:  BoRa Yi; Mi-Ja Kim; JaeHwan Lee
Journal:  Food Sci Biotechnol       Date:  2018-06-01       Impact factor: 2.391

5.  Alpha-tocopherol is essential for acquired chill-light tolerance in the cyanobacterium Synechocystis sp. strain PCC 6803.

Authors:  Yang Yang; Chuntao Yin; Weizhi Li; Xudong Xu
Journal:  J Bacteriol       Date:  2007-12-28       Impact factor: 3.490

6.  Replacement of alpha-tocopherol by beta-tocopherol enhances resistance to photooxidative stress in a xanthophyll-deficient strain of Chlamydomonas reinhardtii.

Authors:  Anchalee Sirikhachornkit; Jai W Shin; Irene Baroli; Krishna K Niyogi
Journal:  Eukaryot Cell       Date:  2009-08-28

7.  Effects of wild-type and α-tocopherol-enriched transgenic Brassica juncea on the components of xenobiotic metabolism, antioxidant status, and oxidative stress in the liver of mice.

Authors:  Manju Singh; Deepak Kumar; Mohd Aslam Yusuf; Meryam Sardar; Neera Bhalla Sarin
Journal:  Transgenic Res       Date:  2013-02-03       Impact factor: 2.788

8.  Tocotrienols, the unsaturated forms of vitamin E, can function as antioxidants and lipid protectors in tobacco leaves.

Authors:  Michel Matringe; Brigitte Ksas; Pascal Rey; Michel Havaux
Journal:  Plant Physiol       Date:  2008-04-25       Impact factor: 8.340

9.  Vitamin E is essential for seed longevity and for preventing lipid peroxidation during germination.

Authors:  Scott E Sattler; Laura U Gilliland; Maria Magallanes-Lundback; Mike Pollard; Dean DellaPenna
Journal:  Plant Cell       Date:  2004-05-21       Impact factor: 11.277

10.  Modulation of antioxidant machinery in α-tocopherol-enriched transgenic Brassica juncea plants tolerant to abiotic stress conditions.

Authors:  Deepak Kumar; Mohd Aslam Yusuf; Preeti Singh; Meryam Sardar; Neera Bhalla Sarin
Journal:  Protoplasma       Date:  2013-01-30       Impact factor: 3.356
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