Literature DB >> 7120276

Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen.

D C Dahlin, S D Nelson.   

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Year:  1982        PMID： 7120276     DOI： 10.1021/jm00350a001

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  17 in total

1.  The metabolism of drugs by the gut flora.

Authors:  M Mikov
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Jul-Sep       Impact factor: 2.441

Review 2.  Mechanisms of acetaminophen-induced liver necrosis.

Authors:  Jack A Hinson; Dean W Roberts; Laura P James
Journal:  Handb Exp Pharmacol       Date:  2010

3.  Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity.

Authors:  Jingxiang Bai; Arthur I Cederbaum
Journal:  Mol Cell Biochem       Date:  2004-07       Impact factor: 3.396

4.  Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites.

Authors:  Peter D Senter; Yousef Al-Abed; Christine N Metz; Fabio Benigni; Robert A Mitchell; J Chesney; Jianlin Han; Carlos G Gartner; Sidney D Nelson; George J Todaro; Richard Bucala
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-02       Impact factor: 11.205

5.  A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes.

Authors:  N R Kitteringham; C Lambert; J L Maggs; J Colbert; B K Park
Journal:  Br J Clin Pharmacol       Date:  1988-07       Impact factor: 4.335

Review 6.  Filling and mining the reactive metabolite target protein database.

Authors:  Robert P Hanzlik; Jianwen Fang; Yakov M Koen
Journal:  Chem Biol Interact       Date:  2008-09-06       Impact factor: 5.192

7.  S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.

Authors:  James Mike Brown; Christopher Kuhlman; Marcus V Terneus; Matthew T Labenski; Andre Benja Lamyaithong; John G Ball; Serrine S Lau; Monica A Valentovic
Journal:  Toxicol Appl Pharmacol       Date:  2014-09-22       Impact factor: 4.219

8.  Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.

Authors:  Shakila Tobwala; Ahdab Khayyat; Weili Fan; Nuran Ercal
Journal:  Exp Biol Med (Maywood)       Date:  2014-09-21

9.  Intrahepatic delivery of glutathione by conjugation to dextran.

Authors:  Y Kaneo; Y Fujihara; T Tanaka; Y Kozawa; H Mori; S Iguchi
Journal:  Pharm Res       Date:  1989-12       Impact factor: 4.200

10.  Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.

Authors:  D W Roberts; T J Bucci; R W Benson; A R Warbritton; T A McRae; N R Pumford; J A Hinson
Journal:  Am J Pathol       Date:  1991-02       Impact factor: 4.307
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