Literature DB >> 71198

Comparative chemical structures of human alpha-fetoproteins from fetal serum and from ascites fluid of a patient with hepatoma.

Y Aoyagi, T Ikenaka, F Ichida.   

Abstract

Human alpha-fetoproteins were purified from umbilical cord serum and from ascites fluid of a patient with hepatoma by affinity chromatography, and their chemical compositions and terminal sequences were compared. The amino acid compositions of these alpha-fetoproteins were similar and in good agreement with the values reported by other investigators. The COOH-terminal 5-amino acid sequence determined by carboxypeptidase digestion and the NH2-terminal 20-amino acid sequence determined by an automated sequence analyzer revealed that both alpha-fetoproteins had the same terminal sequences of amino acids. The sequence analysis showed that a part of each of the proteins lacked its NH2-terminal residues for one or three amino acids. A small difference in the carbohydrate composition of each alpha-fetoprotein was observed. It was concluded that alpha-fetoproteins from fetal serum and from ascites fluid of a patient with hepatoma had very similar structures.

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Year:  1977        PMID： 71198

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  9 in total

1.  Synthesis and copper(II)-binding properties of the N-terminal peptide of human alpha-fetoprotein.

Authors:  S J Lau; J P Laussac; B Sarkar
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

2.  The sequence of human serum albumin cDNA and its expression in E. coli.

Authors:  R M Lawn; J Adelman; S C Bock; A E Franke; C M Houck; R C Najarian; P H Seeburg; K L Wion
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

3.  alpha 1-Fetoprotein mRNA of rat yolk sac and hepatoma.

Authors:  J F Chiu; W Decha-Umphai; P Commer
Journal:  Nucleic Acids Res       Date:  1979-09-11       Impact factor: 16.971

4.  Primary structures of human alpha-fetoprotein and its mRNA.

Authors:  T Morinaga; M Sakai; T G Wegmann; T Tamaoki
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

5.  Further characterization of the N-terminal copper(II)- and nickel(II)-binding motif of proteins. Studies of metal binding to chicken serum albumin and the native sequence peptide.

Authors:  P F Predki; C Harford; P Brar; B Sarkar
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

6.  Metal-protein interactions in transport, accumulation, and excretion of metals.

Authors:  B Sarkar
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

7.  Biochemical characterization of alpha-fetoprotein and other serum proteins produced by a uterine endometrial adenocarcinoma.

Authors:  Y Koyama; K Taketa; M Azuma; R Yamamoto; S Fujimoto; S Nishi
Journal:  Jpn J Cancer Res       Date:  1996-06

8.  Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans.

Authors:  Y Aoyagi; Y Suzuki; K Igarashi; A Saitoh; M Oguro; T Yokota; S Mori; T Suda; M Isemura; H Asakura
Journal:  Br J Cancer       Date:  1993-03       Impact factor: 7.640

9.  Close topographical relationship in alpha foetoprotein (AFP) between a lens culinaris binding glycan and the epitope recognized by AFP-reactive monoclonal antibody, 18H4.

Authors:  Y Suzuki; Y Aoyagi; M Muramatsu; C Sekine; M Isemura; F Ichida
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640
  9 in total

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