Literature DB >> 7119511

The kidney is the main site of interferon catabolism.

V Bocci, A Pacini, M Muscettola, G P Pessina, L Paulesu, L Bandinelli.   

Abstract

The fate of human natural interferons alpha and beta and of recombinant (R) alpha 2 has been investigated by using an isolated and perfused rabbit kidney preparation with a normal physiological performance. A remarkable amount of IFN is filtrated in a monoexponential fashion, reabsorbed and very likely degraded in tubular cells with negligible excretion in the urine. The disappearance rate of HuRIFN-alpha 2 is higher than natural HuIFNs-alpha and beta and is in keeping with the lower molecular weight of RIFN-alpha 2. Differences in molecular charge or shape are probably responsible for the slightly reduced filtration of IFN-beta. Pharmacokinetic studies in animal models appear instructive and useful for devising improved dosage schedules in clinical trials.

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Year:  1982        PMID： 7119511     DOI： 10.1089/jir.1982.2.309

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


  10 in total

1.  Single-dose pharmacokinetics and tolerability of pegylated interferon-alpha2b in young and elderly healthy subjects.

Authors:  Samir K Gupta; Paul Glue; Sheila Jacobs; Donna Belle; Melton Affrime
Journal:  Br J Clin Pharmacol       Date:  2003-07       Impact factor: 4.335

Review 2.  Clinical pharmacokinetics of interferons.

Authors:  R J Wills
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447

3.  Scintigraphic study of radiolabelled interferon-alpha in osteosarcoma patients.

Authors:  R A Diez; B Perdereau; M Peter; T Dorval; R Gongora; E T Falcoff
Journal:  Clin Pharmacokinet       Date:  1990-01       Impact factor: 6.447

4.  The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma.

Authors:  V Bocci; M Muscettola; G Grasso; Z Magyar; A Naldini; G Szabo
Journal:  Experientia       Date:  1986-04-15

Review 5.  Catabolism of interferons.

Authors:  V Bocci
Journal:  Surv Immunol Res       Date:  1982

6.  Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap.

Authors:  Yan Liu; Tarek M El-Achkar; Xue-Ru Wu
Journal:  J Biol Chem       Date:  2012-03-27       Impact factor: 5.157

Review 7.  Interferon-alpha in malignant and viral diseases. A review.

Authors:  R T Dorr
Journal:  Drugs       Date:  1993-02       Impact factor: 9.546

Review 8.  Interleukins. Clinical pharmacokinetics and practical implications.

Authors:  V Bocci
Journal:  Clin Pharmacokinet       Date:  1991-10       Impact factor: 6.447

9.  Multiple-dose pharmacokinetics of peginterferon alfa-2b in patients with renal insufficiency.

Authors:  Samir K Gupta; Suzanne K Swan; Thomas Marbury; William Smith; Sherwyn Schwartz; Karen Kolz; David L Cutler
Journal:  Br J Clin Pharmacol       Date:  2007-06-06       Impact factor: 4.335

10.  Treatment of metastatic renal cell carcinoma with subcutaneous interleukin 2: evidence for non-renal clearance of cytokines.

Authors:  R E Banks; M A Forbes; S Hallam; A Jenkins; M Wadhwa; P Dilger; A Meager; R Thorpe; C J Bowmer; J K Joffe; P Patel; P W Johnson; P J Selby
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640
  10 in total

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