Literature DB >> 7118937

Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog.

P M Cullis, R Wolfenden, L S Cousens, B M Alberts.   

Abstract

A multisubstrate analog, formed by joining coenzyme A with spermidine through an acetic acid linkage, serves as a strong inhibitor (Ki less than 10(-8) M) of the acetylation of spermidine and histones by histone acetylase purified from calf thymus. In free solutions, this analog inhibited acetylation of the various nuclear histones to a similar extent. In isolated nuclei, this analog was found to inhibit acetylation of histones H2a and H2b very much more strongly than that of histones H3 and H4.

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Year:  1982        PMID： 7118937

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

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2.  Polyamine N-acetyltransferase in Leishmania amazonensis.

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5.  Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase.

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Review 8.  Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease.

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Review 9.  Histone modification and histone modification-targeted anti-cancer drugs in breast cancer: Fundamentals and beyond.

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Journal:  Front Pharmacol       Date:  2022-09-15       Impact factor: 5.988
  9 in total

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