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Literature DB >> 7118581

Distribution of DNA between sister cells during serial subcultivation of human fibroblasts.

A Macieira-Coelho, A Bengtsson, M Van der Ploeg.

Abstract

The segregation of DNA at the time of cell division was analysed by measuring the DNA contents of cells in mitosis and the incorporation of tritiated thymidine (3H-TdR) on each half of anaphases and telophases. Results suggest that the spreads in the 2C and 4C DNA contents are due to quantitative differences which could originate during semi-conservative DNA synthesis, chromosome assembly and chromosome segregation. This continuous rearrangement of the genome could lead either to a degenerative process or to a differentiation program.

Entities: Chemical Species

Mesh：

Substances：
DNA

Year: 1982 PMID： 7118581 DOI： 10.1007/bf00492529

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

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References

30 in total

9. Effect of short- or long-term treatment with exogenous glycosaminoglycans on growth and glycosaminoglycan synthesis of human fibroblasts (WI-38) in culture.

Authors: J Wever; D O Schachtschabel; G Sluke; G Wever
Journal: Mech Ageing Dev Date: 1980 Sep-Oct Impact factor: 5.432

10. Evidence for an increased level of DNA damage in high doubling level human diploid cells culture.

Authors: R T Dell'Orco; W L Whittle
Journal: Mech Ageing Dev Date: 1981-02 Impact factor: 5.432

Distribution of DNA between sister cells during serial subcultivation of human fibroblasts.

1. Chromatin template activity during aging in WI38 cells.

2. DNA-binding proteins in young and senescent normal human fibroblasts.

3. Kinetics of the proliferation of human fibroblasts during their lifespan in vitro.

4. The cell cycle during growth inhibition of human embryonic fibroblasts in vitro.

5. Ultrastructural organization of nucleoproteins during aging of cultured human embryonic fibroblasts.

6. HIDACSYS: computer programs for interactive scanning cytophotometry.

7. The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro.

8. Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts.

9. Effect of short- or long-term treatment with exogenous glycosaminoglycans on growth and glycosaminoglycan synthesis of human fibroblasts (WI-38) in culture.

10. Evidence for an increased level of DNA damage in high doubling level human diploid cells culture.