Literature DB >> 7118185

Suppression of humoral and cellular immunity in normal mice by diazepam.

J Descotes, R Tedone, J C Evreux.   

Abstract

Diazepam, a benzodiazepine derivative useful in the treatment of anxiety disorders, was found to depress both primary antibody to sheep red blood cells and delayed-type hypersensitivity responses in normal mice. This immunodepressant activity warrants further investigation owing to its potential consequences on human health and the putative involvement of specific receptors on immunocompetent cells.

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Year:  1982        PMID: 7118185     DOI: 10.1016/0165-2478(82)90089-x

Source DB:  PubMed          Journal:  Immunol Lett        ISSN: 0165-2478            Impact factor:   3.685


  3 in total

1.  Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation.

Authors:  M J Parnham; C Bittner; G Lambrecht
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

2.  The effect of prenatal diazepam exposure on TNF-alpha production by rat splenocytes.

Authors:  A A Schreiber; K Frei; W Lichtensteiger; M Schlumpf
Journal:  Agents Actions       Date:  1993-03

Review 3.  Perinatal immunotoxicity: why adult exposure assessment fails to predict risk.

Authors:  Rodney R Dietert; Michael S Piepenbrink
Journal:  Environ Health Perspect       Date:  2006-04       Impact factor: 9.031

  3 in total

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