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Literature DB >> 7117358

Differences between the concentrations of antiepileptic drugs in normal and pathological human brain.

V A Sironi, L Ravagnati, G Ettorre, G P Cabrini, F Marossero.

Abstract

The concentrations of antiepileptic drugs in histologically normal and pathological brain tissues were investigated in 6 patients submitted to surgery. No significant difference for phenobarbital and phenytoin was found between normal and scar tissue, whereas there was a trend to concentration in tumour tissue (meningioma and glioma) of phenobarbital, phenytoin and carbamazepine. Alteration in the vascular supply and pathological changes at cellular and subcellular levels could be responsible for the differences in the distribution of the drugs. The possible clinical relevance of the preferential concentration of the drugs in tumour tissue is discussed.

Entities: Chemical Disease Species

Mesh：

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Year: 1982 PMID： 7117358 DOI： 10.1007/bf00542551

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

15 in total

1. PREFERENTIAL DISTRIBUTION OF DIPHENYLHYDANTOIN IN PRIMARY HUMAN BRAIN TUMORS.

Authors: I ROSENBLUM; A A STEIN
Journal: Biochem Pharmacol Date: 1963-12 Impact factor: 5.858

2. Growth-inhibitory effects of diphenylhydantoin on human brain tumor cells in culture.

Authors: P L Kornblith; L V Callahan; P A Caswell
Journal: Neurosurgery Date: 1978 Mar-Apr Impact factor: 4.654

3. Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma.

Authors: A L Sherwin; A A Wisen; C D Sokolowski
Journal: Arch Neurol Date: 1973-08

2. Anticonvulsant drugs fail to modulate chemotherapy-induced cytotoxicity and growth inhibition of human malignant glioma cells.

Authors: M Ständer; J Dichgans; M Weller
Journal: J Neurooncol Date: 1998-05 Impact factor: 4.130

2 in total

Differences between the concentrations of antiepileptic drugs in normal and pathological human brain.

1. PREFERENTIAL DISTRIBUTION OF DIPHENYLHYDANTOIN IN PRIMARY HUMAN BRAIN TUMORS.

2. Growth-inhibitory effects of diphenylhydantoin on human brain tumor cells in culture.

3. Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma.

4. Human brain, cerebrospinal fluid, and plasma concentrations of diphenylhydantoin and phenobarbital.

5. Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.

6. [Stereo-electroencephalography in the diagnosis of nontumoral epilepsies].

7. Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients.

8. Carbamazepine and carbamazepine-10, 11-epoxide concentrations in human brain.

9. Human epileptic brain Na, K ATPase activity and phenytoin concentrations.

10. Carbamazepine, carbamazepine-10,11-epoxide and phenytoin concentrations in brain tissue of epileptic children.

1. Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.

2. Anticonvulsant drugs fail to modulate chemotherapy-induced cytotoxicity and growth inhibition of human malignant glioma cells.