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Literature DB >> 7117296

Identification of biliary metabolites of mebendazole in the rat.

Abstract

Three metabolites of mebendazole were isolated from the bile of rats dosed with a mixture of mebendazole and pentadeuteromebendazole. The identification was based upon the appearance of the characteristic doublet in the mass spectrum of the compounds and the comparison of their fragmentations with those of authentic compounds. Cochromatography of the metabolites with the authentic compounds on HPLC supported the identification. Methyl-5(6)-(alpha-hydroxybenzyl)-2-benzimidazole carbamate, 2-amino-5(6)-(alpha-hydroxybenzyl) benzimidazole and 2-amino-5(6)-benzoylbenzimidazole were identified as metabolites after enzymic conjugate hydrolysis. Some unmetabolized mebendazole was also found.

Entities: Chemical Species

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Year: 1982 PMID： 7117296 DOI： 10.1007/BF03188730

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441

14 in total

1. Identification of 5-hydroxybenzimidazole as a major urinary metabolite of benzimidazole in the rat.

Authors: T R Tyler; J T Lee; H Flynn; W J Vandenheuvel
Journal: Drug Metab Dispos Date: 1976 Mar-Apr Impact factor: 3.922

2. THE METABOLIC FATE OF THIABENDAZOLE IN SHEEP.

Authors: D J TOCCO; R P BUHS; H D BROWN; A R MATZUK; H E MERTEL; R E HARMAN; N R TRENNER
Journal: J Med Chem Date: 1964-07 Impact factor: 7.446

3. The metabolism of benomyl fungicide in mammals.

Authors: P G Douch
Journal: Xenobiotica Date: 1973-06 Impact factor: 1.908

4. Metabolic and tissue residue studies on parbendazole in sheep.

Authors: C J DiCuollo; J A Miller; W L Mendelson; J F Pagano
Journal: J Agric Food Chem Date: 1974 Nov-Dec Impact factor: 5.279

5. Metabolites of methyl 5(6)-butyl-2-benzimidazolecarbamate (parbendazole). Structure and synthesis.

Authors: G L Dunn; G Gallagher; L D Davis; J R Hoover; R J Stedman
Journal: J Med Chem Date: 1973-09 Impact factor: 7.446

6. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects.

Authors: J P Brugmans; D C Thienpont; I van Wijngaarden; O F Vanparijs; V L Schuermans; H L Lauwers
Journal: JAMA Date: 1971-07-19 Impact factor: 56.272

7. Two high-performance liquid chromatographic determinations for mebendazole and its metabolites in human plasma using a rapid Sep Pak C18 extraction.

Authors: R J Allan; H T Goodman; T R Watson
Journal: J Chromatogr Date: 1980-09-12

Identification of biliary metabolites of mebendazole in the rat.

1. Identification of 5-hydroxybenzimidazole as a major urinary metabolite of benzimidazole in the rat.

2. THE METABOLIC FATE OF THIABENDAZOLE IN SHEEP.

3. The metabolism of benomyl fungicide in mammals.

4. Metabolic and tissue residue studies on parbendazole in sheep.

5. Metabolites of methyl 5(6)-butyl-2-benzimidazolecarbamate (parbendazole). Structure and synthesis.

6. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects.

7. Two high-performance liquid chromatographic determinations for mebendazole and its metabolites in human plasma using a rapid Sep Pak C18 extraction.

8. Biotransformation of methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate (ciclobendazole) in rats and dogs.

9. Chemotherapy of echinococcosis with mebendazole: clinical observations of 7 patients.

10. A clinical trial of mebendazole in the treatment of alveolar hydatid disease.

1. The metabolic and pharmacokinetic disposition of mebendazole in the rat.

2. Efficacy of albendazole and mebendazole against Hymenolepis microstoma and Hymenolepis diminuta.