Literature DB >> 7115317

Stoichiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide.

R L White, E M John, J E Baldwin, E P Abraham.   

Abstract

The biosynthesis of isopenicillin N from delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine in a cell-free system has been correlated wih O2 consumption by two methods, involving the use of an oxygen-electrode and an n.m.r. spectrometer respectively. The results are consistent with a 1 : 1 stoichiometric ratio for the dioxygen consumed to the isopenicillin N formed.

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Year:  1982        PMID： 7115317      PMCID： PMC1158298          DOI： 10.1042/bj2030791

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  2 in total

1.  Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium.

Authors:  T Konomi; S Herchen; J E Baldwin; M Yoshida; N A Hunt; A L Demain
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

2.  Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N.

Authors:  J O'Sullivan; R C Bleaney; J A Huddleston; E P Abraham
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857
  2 in total
  9 in total

1.  Evaluation of two unstructured mathematical models for the penicillin G fed-batch fermentation.

Authors:  B M Nicolaï; J F Van Impe; P A Vanrolleghem; J Vandewalle
Journal:  Antonie Van Leeuwenhoek       Date:  1992-11       Impact factor: 2.271

2.  Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster.

Authors:  Rongfeng Li; Ryan A Oliver; Craig A Townsend
Journal:  Cell Chem Biol       Date:  2016-12-22       Impact factor: 8.116

3.  Purification of isopenicillin N synthetase.

Authors:  C P Pang; B Chakravarti; R M Adlington; H H Ting; R L White; G S Jayatilake; J E Baldwin; E P Abraham
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

Review 4.  Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Authors:  A A Brakhage
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

5.  A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

Authors:  Mary L Raber; Alvaro Castillo; Alexander Greer; Craig A Townsend
Journal:  Chembiochem       Date:  2009-12-14       Impact factor: 3.164

6.  Analysis of penicillin V biosynthesis during fed-batch cultivations with a high-yielding strain of Penicillium chrysogenum.

Authors:  H Jørgensen; J Nielsen; J Villadsen; H Møllgaard
Journal:  Appl Microbiol Biotechnol       Date:  1995-04       Impact factor: 4.813

7.  Factors affecting the isopenicillin N synthetase reaction.

Authors:  D Perry; E P Abraham; J E Baldwin
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

8.  Beta-lactam biosynthesis in a gram-negative eubacterium: purification and characterization of isopenicillin N synthase from Flavobacterium sp. strain SC 12.154.

Authors:  H Palissa; H von Döhren; H Kleinkauf; H H Ting; J E Baldwin
Journal:  J Bacteriol       Date:  1989-10       Impact factor: 3.490

9.  Changes in Oxygen Availability during Glucose-Limited Chemostat Cultivations of Penicillium chrysogenum Lead to Rapid Metabolite, Flux and Productivity Responses.

Authors:  Qi Yang; Wenli Lin; Jiawei Xu; Nan Guo; Jiachen Zhao; Gaoya Wang; Yongbo Wang; Ju Chu; Guan Wang
Journal:  Metabolites       Date:  2022-01-07
  9 in total

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