Literature DB >> 711378

Inhibition of thrombin and trypsin by tripeptide aldehydes.

S Bajusz, E Barabás, P Tolnay, E Széll, D Bagdy.   

Abstract

Inhibitory effects of certain tripeptide aldehydes on both thrombin and trypsin have been found to be strongly substrate-dependent. These compounds should therefore be considered as inhibitors of the particular proteolytic reaction for which they had been designed rather than real enzyme inhibitors, i.e. protein or polypeptide proteinase inhibitors of natural origin.

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Year:  1978        PMID： 711378     DOI： 10.1111/j.1399-3011.1978.tb02889.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  9 in total

1.  Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin.

Authors:  F A Ofosu; J W Fenton; J Maraganore; M A Blajchman; X Yang; L Smith; N Anvari; M R Buchanan; J Hirsh
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

2.  Dissimilar responsiveness of cultured corticotrophs and melanotrophs to tripeptide aldehydes.

Authors:  I Fazekas; G Rappay; E Bácsy; H Medzihradszky-Schweiger; A Gyévai; G Gaál
Journal:  Histochemistry       Date:  1986

3.  Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins.

Authors:  Adam J T Smith; Xiyun Zhang; Andrew G Leach; K N Houk
Journal:  J Med Chem       Date:  2009-01-22       Impact factor: 7.446

4.  Benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycine: a novel inhibitor of thrombin with high selectivity containing a neutral side chain at the P1 position.

Authors:  G Claeson; M Philipp; E Agner; M F Scully; R Metternich; V V Kakkar; T DeSoyza; L H Niu
Journal:  Biochem J       Date:  1993-03-01       Impact factor: 3.857

5.  The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.

Authors:  W Bode; D Turk; A Karshikov
Journal:  Protein Sci       Date:  1992-04       Impact factor: 6.725

6.  Preparations of psi-peptide bond and peptide-aldehyde inhibitors of atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor.

Authors:  A Damodaran; R B Harris
Journal:  J Protein Chem       Date:  1995-08

7.  Calcium ion uptake, somatotropin release, and fine structure of somatotrophs in cultures of the rat anterior pituitary upon the action of an oligopeptide (Boc-Gln-Leu-Lysinal).

Authors:  G Rappay; G B Makara; G Gaál; V Garamvölgyi; I Nagy; S Bajusz; G Széll
Journal:  Histochemistry       Date:  1989

8.  Thrombin-specific inhibition by and slow cleavage of hirulog-1.

Authors:  J I Witting; P Bourdon; D V Brezniak; J M Maraganore; J W Fenton
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

9.  The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

Authors:  W Bode; I Mayr; U Baumann; R Huber; S R Stone; J Hofsteenge
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
  9 in total

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