| Literature DB >> 7113697 |
S Helgason, J E Damber, M G Damber, B von Schoultz, G Selstam, R Södergård.
Abstract
An aqueous two-phase equilibrium partition system was used to assay SHBG-binding capacity. Sera from groups of postmenopausal women before and during unopposed estrogen replacement therapy were analyzed. The induction of SHBG showed considerable differences between different estrogens. Ethinyl-estradiol in a daily dose of 0.05 mg gave a 70% increase in the serum concentration of this liver derived protein. Estradiol-17 beta, 2 mg daily and estrone sulphate 1.25 mg gave moderate changes, whereas estriol in different doses had no effect. SHBG induction may reflect estrogen overtreatment.Entities:
Mesh：
Substances：
Year: 1982 PMID： 7113697 DOI： 10.3109/00016348209156536
Source DB: PubMed Journal: Acta Obstet Gynecol Scand ISSN： 0001-6349 Impact factor: 3.636