Literature DB >> 7112603

Excretion of TTCA in human urine after administration of disulfiram.

R van Doorn, C M Leijdekkers, S M Nossent, P T Henderson.   

Abstract

2-Thiothiazolidine-4-carboxylic acid (TTCA) was measured in urine of two persons given an oral dose of 250 mg disulfiram. Maximum concentrations up to 0.33 mmol TTCA/mol creatinine were found, 10 to 14 h after dosing. The total amounts of TTCA excreted in urine were 1.8 and 3.5 mumol, respectively, which correspond to 0.2 and 0.4% of the dose.

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Year:  1982        PMID： 7112603     DOI： 10.1016/0378-4274(82)90199-0

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  3 in total

1.  Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries.

Authors:  Lena S Jönsson; Karin Broberg; Ulf Bergendorf; Anna Axmon; Margareta Littorin; Bo A G Jönsson
Journal:  Int Arch Occup Environ Health       Date:  2007-02-28       Impact factor: 3.015

2.  Dietary habits, a non-negligible source of 2-thiothiazolidine-4-carboxylic acid and possible overestimation of carbon disulfide exposure.

Authors:  P Simon; T Nicot; M Dieudonné
Journal:  Int Arch Occup Environ Health       Date:  1994       Impact factor: 3.015

3.  Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans.

Authors:  R T van Welie; P van Duyn; E K Lamme; P Jäger; B L van Baar; N P Vermeulen
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015
  3 in total

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