Literature DB >> 7110914

Bioavailability of methotrexate tablets.

J H Schornagel, M E Van Engelen, D De Vos.   

Abstract

The bioavailability of methotrexate 10 mg tablets has been determined to be 62 +/- 16%. After administration of a dose of 30 mg/m2 a maximum plasma concentration of ca. 20.10(-7) mole/l was found after ca. 1.7 h. The methotrexate plasma half-life was 2.4 h. It was concluded that the 10 mg tablet formulation at the dosage investigated is a suitable clinical methotrexate preparation.

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Year:  1982        PMID： 7110914     DOI： 10.1007/bf01962252

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  6 in total

1.  Effect of route of administration and effusions on methotrexate pharmacokinetics.

Authors:  S H Wan; D H Huffman; D L Azarnoff; R Stephens; B Hoogstraten
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

2.  The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man.

Authors:  E S Henderson; R H Adamson; V T Oliverio
Journal:  Cancer Res       Date:  1965-08       Impact factor: 12.701

3.  Enhancement of methotrexate absorption by subdivision of dose.

Authors:  W H Steele; J F Stuart; J R Lawrence; C A McNeill; W E Sneader; B Whiting; K C Calman; J G McVie
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

4.  Bioavailability of methotrexate: implications for clinical use.

Authors:  J F Stuart; K C Calman; J Watters; J Paxton; B Whiting; J R Lawrence; W H Steele; J G McVie
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

Review 5.  The clinical pharmacology of methotrexate: new applications of an old drug.

Authors:  W A Bleyer
Journal:  Cancer       Date:  1978-01       Impact factor: 6.860

6.  Comparison of intravenous and oral high-dose methotrexate in treatment of solid tumours.

Authors:  N Christophidis; F J Vajda; I Lucas; W J Moon; W J Louis
Journal:  Br Med J       Date:  1979-02-03
  6 in total
  2 in total

Review 1.  Pharmacokinetics of anticancer drugs in children.

Authors:  W R Crom; A M Glynn-Barnhart; J H Rodman; M E Teresi; R E Kavanagh; M L Christensen; M V Relling; W E Evans
Journal:  Clin Pharmacokinet       Date:  1987-03       Impact factor: 6.447

2.  Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.

Authors:  Kayode Ogungbenro; Leon Aarons
Journal:  J Pharmacokinet Pharmacodyn       Date:  2014-03-21       Impact factor: 2.745
  2 in total

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