Literature DB >> 7108149

Inhibition of killer cell cytotoxicity induced by carbimazole in vitro.

P Pozzilli, M Sensi, D Andreani.   

Abstract

The in vitro effect mediated by carbimazole (CBZ), a classical anti-thyroid agent on the antibody dependent cellular cytotoxicity (ADCC), low affinity E-rosetting cells (E-RFC) and high affinity E-RFC was investigated using lymphocytes from 11 normal subjects. CBZ at the doses of 250 and 500 mumol/l significantly reduced ADCC in all subjects studied. Low affinity E-RFC--mainly cells possessing receptors for the Fc portion of IgG and expressing cytotoxic properties in the ADCC system--were also significantly reduced following incubation with the same CBZ doses. These results suggest that CBZ, in addition to the known inhibitory effect on thyroid hormone synthesis, may be useful by depressing lymphocyte cytotoxicity in the treatment of autoimmune thyroid disease.

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Year:  1982        PMID： 7108149     DOI： 10.1007/BF03349469

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  20 in total

1.  Pharmacokinetics of propylthiouracil in man after a single oral dose.

Authors:  D S Sitar; D B Hunninghake
Journal:  J Clin Endocrinol Metab       Date:  1975-01       Impact factor: 5.958

2.  Human T lymphocyte subpopulations: correlation between E-rosette-forming affinity and expression of the Fc receptor.

Authors:  W H West; S M Payne; J L Weese; R B Herberman
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

3.  Lymphocytes with T-cell markers cooperate with IgG antibodies in the lysis of human tumour cells.

Authors:  J G Saal; E P Rieber; M Hadam; G Riethmuller
Journal:  Nature       Date:  1977-01-13       Impact factor: 49.962

4.  The acclumulation of 35 S-antithyroid drugs by the thyroid gland.

Authors:  B Marchant; W D Alexander; J H Lazarus; J Lees; D H Clark
Journal:  J Clin Endocrinol Metab       Date:  1972-05       Impact factor: 5.958

5.  Effects of antithyroid therapy on the long-acting thyroid stimulator and the antithyroglobulin antibodies.

Authors:  A Pinchera; P Liberti; E Martino; G F Fenzi; L Grasso; L Rovis; L Baschieri; G Doria
Journal:  J Clin Endocrinol Metab       Date:  1969-02       Impact factor: 5.958

6.  Lymphoid tissue in the thyroid gland and thymus of patients with primary thyrotoxicosis.

Authors:  J S Beck; R J Young; J G Simpson; E S Gray; A G Nicol; C A Pegg; W Michie
Journal:  Br J Surg       Date:  1973-10       Impact factor: 6.939

7.  Low affinity E-rosette formation by the human K cell.

Authors:  W H West; R B Boozer; R B Herberman
Journal:  J Immunol       Date:  1978-01       Impact factor: 5.422

8.  T, B and K cells in autoimmune thyroid disease.

Authors:  E A Calder; W J Irvine; N M Davidson; F Wu
Journal:  Clin Exp Immunol       Date:  1976-07       Impact factor: 4.330

9.  Effects of antithyroid drugs on lymphocyte function in vitro.

Authors:  B Hallengren; A Forsgren; A Melander
Journal:  J Clin Endocrinol Metab       Date:  1980-08       Impact factor: 5.958

10.  Increased killer cell activity in insulin dependent (type 1) diabetes mellitus.

Authors:  M Sensi; P Pozzilli; A N Gorsuch; G F Bottazzo; A G Cudworth
Journal:  Diabetologia       Date:  1981-02       Impact factor: 10.122
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  1 in total

1.  Inhibition of the receptor for interleukin-2 induced by carbimazole: relevance for the therapy of autoimmune thyroid disease.

Authors:  A Signore; P Pozzilli; U Di Mario; M Sensi; P Beales; D Andreani
Journal:  Clin Exp Immunol       Date:  1985-04       Impact factor: 4.330
  1 in total

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