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Literature DB >> 7107959

C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.

K P Schofield, F Voulgari, D I Gozzard, M J Leyland, N J Beeching, J Stuart.

Abstract

Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 7107959 PMCID： PMC497805 DOI： 10.1136/jcp.35.8.866

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

6 in total

1. Rabbit CRP response to endotoxin administration: dose-response relationship and kinetics.

Authors: B Yen-Watson; I Kushner
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2. Granulocyte transfusion: where now?

Authors: D J Higby
Journal: N Engl J Med Date: 1981-09-10 Impact factor: 91.245

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Authors: M W Kenny; D J Worthington; J Stuart; A J Davies; M Farr; P G Davey; M A Chughtai
Journal: Clin Lab Haematol Date: 1981

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Authors: M B Pepys
Journal: Lancet Date: 1981-03-21 Impact factor: 79.321

5. Serial study of C-reactive protein during infection in leukaemia.

Authors: P E Rose; S A Johnsdon; M Meakin; P H Mackie; J Stuart
Journal: J Clin Pathol Date: 1981-03 Impact factor: 3.411

6. The liver as the site of C-reactive protein formation.

Authors: J Hurlimann; G J Thorbecke; G M Hochwald
Journal: J Exp Med Date: 1966-02-01 Impact factor: 14.307

6 in total

16 in total

1. C-reactive protein in the management of children with fever after allogeneic bone marrow transplantation.

Authors: C de Bel; E Gerritsen; G de Maaker; A Moolenaar; J Vossen
Journal: Infection Date: 1991 Mar-Apr Impact factor: 3.553

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Authors: R E Moreton; C R Kennedy
Journal: Arch Dis Child Date: 1988-08 Impact factor: 3.791

3. Value of serum C-reactive protein measurement in the management of bone marrow transplant recipients. Part I: Early transplant period.

Authors: S A Walker; T R Rogers; P G Riches; S White; J R Hobbs
Journal: J Clin Pathol Date: 1984-09 Impact factor: 3.411

4. Measurement of serum C reactive protein concentration after bone marrow transplantation for leukaemia.

Authors: I F Rowe; A M Worsley; P Donnelly; D Catovsky; J M Goldman; D Galton; M B Pepys
Journal: J Clin Pathol Date: 1984-03 Impact factor: 3.411

5. C-reactive protein as an indicator of resolution of sepsis in the intensive care unit.

Authors: S M Yentis; N Soni; J Sheldon
Journal: Intensive Care Med Date: 1995-07 Impact factor: 17.440

6. C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients.

Authors: R I Harris; P C Stone; A G Hudson; J Stuart
Journal: J Clin Pathol Date: 1984-07 Impact factor: 3.411

7. Serial concentrations of C-reactive protein as an indicator of urinary tract infection in patients with spinal injury.

Authors: A Galloway; H T Green; J J Windsor; K K Menon; B P Gardner; K R Krishnan
Journal: J Clin Pathol Date: 1986-08 Impact factor: 3.411