Literature DB >> 7107641

Human hypoxanthine-guanine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme.

J M Wilson, G E Tarr, W C Mahoney, W N Kelley.   

Abstract

The entire amino acid sequence of hypoxanthine-guanine phosphoribosyltransferase from human erythrocytes has been defined. Peptide fragments formed by cleavage at arginine, glutamic acid, and methionine residues were analyzed by Edman degradation or digestion with carboxypeptidase. The complete primary structure of human hypoxanthine-guanine phosphoribosyltransferase was established by sequence analysis of 17 peptide fragments, 15 of which were purified by reverse-phase high pressure liquid chromatography. The enzyme is 217 residues long with a molecular weight equal to 24,470. Mass spectroscopy indicated that the NH2-terminal alanine is acetylated.

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Year:  1982        PMID： 7107641

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  18 in total

1.  Identification of a single nucleotide substitution in the coding sequence of in vitro amplified cDNA from a patient with partial HPRT deficiency (HPRTBRISBANE).

Authors:  R B Gordon; D G Sculley; P A Dawson; I R Beacham; B T Emmerson
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982

2.  Genetic diseases, immunology, viruses, and gene therapy.

Authors:  James M Wilson
Journal:  Hum Gene Ther       Date:  2014-04       Impact factor: 5.695

3.  A Comparison of Two Sucrose Synthetase Isozymes from Normal and shrunken-1 Maize.

Authors:  C S Echt; P S Chourey
Journal:  Plant Physiol       Date:  1985-10       Impact factor: 8.340

4.  Inherited disorders of purine metabolism--underlying molecular mechanisms.

Authors:  W Gutensohn
Journal:  Klin Wochenschr       Date:  1984-10-15

5.  Human hypoxanthine-guanine phosphoribosyltransferase: studies of the normal and five mutant forms of the enzyme.

Authors:  W N Kelley; J M Wilson
Journal:  Trans Am Clin Climatol Assoc       Date:  1983

6.  Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout.

Authors:  J M Wilson; G E Tarr; W N Kelley
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

7.  Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome.

Authors:  J M Wilson; W N Kelley
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

8.  A germ line mutation within the coding sequence for the putative 5-phosphoribosyl-1-pyrophosphate binding site of hypoxanthine-guanine phosphoribosyltransferase (HPRT) in a Lesch-Nyhan patient: missense mutations within a functionally important region probably cause disease.

Authors:  S Fujimori; T Tagaya; N Kamatani; I Akaoka
Journal:  Hum Genet       Date:  1992-12       Impact factor: 4.132

9.  Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy.

Authors:  S P Craig; J H McKerrow; G R Newport; C C Wang
Journal:  Nucleic Acids Res       Date:  1988-07-25       Impact factor: 16.971

10.  A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man.

Authors:  J M Wilson; J T Stout; T D Palella; B L Davidson; W N Kelley; C T Caskey
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808
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