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Literature DB >> 710753

Thickening of glomerular basement membrane in spontaneously diabetic rats.

S Yagihashi, Y Goto, M Kakizaki, N Kaseda.

Abstract

The glomerular basement membrane of spontaneously diabetic rats was investigated by quantitative analysis using electron microscopy, with special reference to the effect of ageing. Constant age-related increase in the width of basement membrane was ascertained both in diabetic and control rats, and the mean values of basement membrane thickness were always higher in the spontaneously diabetic rats than in normal control rats. Significant thickening of glomerular basement membrane was found in the diabetic rats at 12 weeks of age, while younger diabetic rats had no definite increase. The difference in basement membrane thickness between diabetic and normal control rats became larger with increasing age.

Entities: Disease Species

Mesh：

Substances：
Blood Glucose

Year: 1978 PMID： 710753 DOI： 10.1007/bf02573824

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

9 in total

1. Diabetes mellitus in the Chinese hamster. II. The evolution of renal glomerulopathy.

Authors: T Shirai; G W Welsh; E A Sims
Journal: Diabetologia Date: 1967-04 Impact factor: 10.122

2. Variations in capillary basement membrane width produced by aging and diabetes mellitus.

Authors: J M Bloodworth; R L Engerman; R A Camerini-Dávalos; K L Powers
Journal: Adv Metab Disord Date: 1970

3. The kidney of spiny mice (Acomys cahirinus): electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia.

Authors: L Orci; W Stauffacher; M Amherdt; R Pictet; A E Renold; C Rouiller
Journal: Diabetologia Date: 1970-06 Impact factor: 10.122

4. Thickness of glomerular basement membranes.

Authors: G Osawa; P Kimmelstiel; V Seiling
Journal: Am J Clin Pathol Date: 1966-01 Impact factor: 2.493

5. Production of spontaneous diabetic rats by repetition of selective breeding.

Authors: Y Goto; M Kakizaki; N Masaki
Journal: Tohoku J Exp Med Date: 1976-05 Impact factor: 1.848

6. Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.

Authors: A A Like; R L Lavine; P L Poffenbarger; W L Chick
Journal: Am J Pathol Date: 1972-02 Impact factor: 4.307

7. Quantitative estimation of age-related thickening of glomerular basement membrane in normal rats.

Authors: S Yagihashi
Journal: Tohoku J Exp Med Date: 1978-09 Impact factor: 1.848

8. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors: E S REYNOLDS
Journal: J Cell Biol Date: 1963-04 Impact factor: 10.539

9. TECHNICAL MODIFICATIONS IN MARAGLAS EMBEDDING.

Authors: B O Spurlock; V C Kattine; J A Freeman
Journal: J Cell Biol Date: 1963-04-01 Impact factor: 10.539

9 in total

12 in total

1. Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats.

Authors: Kazuko Momose; Shin Nunomiya; Masanori Nakata; Toshihiko Yada; Motoshi Kikuchi; Takashi Yashiro
Journal: Med Mol Morphol Date: 2006-09 Impact factor: 2.309

2. Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats.

Authors: Naoki Kojima; Tiffani N Slaughter; Adrienne Paige; Sota Kato; Richard J Roman; Jan M Williams
Journal: J Diabetes Metab Date: 2013-05-30

3. Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.

Authors: Sachin Gupte; Nazar Labinskyy; Rakhee Gupte; Anna Csiszar; Zoltan Ungvari; John G Edwards
Journal: PLoS One Date: 2010-07-26 Impact factor: 3.240

Thickening of glomerular basement membrane in spontaneously diabetic rats.

1. Diabetes mellitus in the Chinese hamster. II. The evolution of renal glomerulopathy.

2. Variations in capillary basement membrane width produced by aging and diabetes mellitus.

3. The kidney of spiny mice (Acomys cahirinus): electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia.

4. Thickness of glomerular basement membranes.

5. Production of spontaneous diabetic rats by repetition of selective breeding.

6. Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.

7. Quantitative estimation of age-related thickening of glomerular basement membrane in normal rats.

8. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

9. TECHNICAL MODIFICATIONS IN MARAGLAS EMBEDDING.

1. Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats.

2. Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats.

3. Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.

4. Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats.

5. Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat.

6. Abnormal metabolism of polyunsaturated fatty acids and phospholipids in diabetic glomeruli.

Review 7. Rodent models of diabetic nephropathy: their utility and limitations.

8. Phenotypic Characterization of LEA Rat: A New Rat Model of Nonobese Type 2 Diabetes.

Review 9. An Update on the Use of Animal Models in Diabetic Nephropathy Research.

10. Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats.