Generalized parvovirus disease in neonatal pups.

Generalized canine parvovirus disease was diagnosed in a litter of pups that died when 3 to 9 days old. Parvovirus was isolated from the heart, lungs, liver, kidneys, and small intestine. Histologically, lesions were characterized by hemorrhage and necrosis in the brain, liver, lungs, kidneys, lymphoid tissues, and gastrointestinal mucosa. Intranuclear inclusions were found in vascular endothelium, heart, lungs, liver, kidneys, adrenal cortex, and gastrointestinal tract.