| Literature DB >> 7107028 |
A W Wheeler, D M Moran, B E Robins, A Driscoll.
Abstract
A series of experiments has been carried out to investigate the adjuvant properties of the amino acid L-tyrosine in laboratory animals. Adsorption of various allergenic materials to L-tyrosine was found to enhance the induction of IgG antibodies, but no unusual propensity to stimulate IgE antibody or delayed hypersensitivity was observed. Administration of the amino acid at a site remote from the allergen was found not to augment antibody production. This, together with evidence of reduced bioavailability of the tyrosine-adsorbed allergen, suggested that the adjuvant activity observed resulted from a short-term depot effect.Entities:
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Year: 1982 PMID： 7107028 DOI： 10.1159/000233157
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915