Literature DB >> 7106445

Apolipoprotein C in type 2 (non-insulin-dependent) diabetic patients with hypertriglyceridaemia.

A F Stalenhoef, P N Demacker, J A Lutterman, A van't Laar.   

Abstract

The composition of apolipoprotein C of the very low density lipoproteins (VLDL) was examined in 23 treated Type 2 (non-insulin-dependent) diabetic patients, who had elevated VLDL concentrations. Apolipoprotein C was separated by isoelectric focussing into apolipoprotein C-II which is known as the specific activator of lipoprotein lipase, and three apolipoprotein C-III fragments. A regulatory role has been ascribed to the ratio of apolipoprotein C-II to apolipoprotein C-III in the removal of plasma triglycerides. In our diabetic group, the composition of apolipoprotein C of the VLDL particles was not different from that of a healthy control group. In particular, the above apolipoprotein ratio and the relative amounts of apolipoprotein C-III fragments were normal. Hypertriglyceridaemia in these diabetic subjects does not seem to be related to alterations in the apolipoprotein C composition.

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Year:  1982        PMID： 7106445     DOI： 10.1007/BF00282597

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  10 in total

1.  Apolipoprotein C-II and C-III levels in hyperlipoproteinemia.

Authors:  G Schonfeld; P K George; J Miller; P Reilly; J Witztum
Journal:  Metabolism       Date:  1979-10       Impact factor: 8.694

2.  Type III hyperlipoproteinemia: development of a VLDL ApoE gel isoelectric focusing technique and application in family studies.

Authors:  S W Weidman; B Suarez; J M Falko; J L Witztum; J Kolar; M Raben; G Schonfeld
Journal:  J Lab Clin Med       Date:  1979-04

3.  Evaluation of the dual-precipitation method by comparison with the ultracentrifugation method for measurement of lipoproteins in serum.

Authors:  P N Demacker; H E Vos-Janssen; A P Jansen; A van 't Laar
Journal:  Clin Chem       Date:  1977-07       Impact factor: 8.327

4.  Abnormal preponderance of sialylated apolipoprotein CIII in triglyceride rich lipoproteins in type V hyperlipoproteinemia.

Authors:  M L Kashyap; B A Hynd; K Robinson; P S Gartside
Journal:  Metabolism       Date:  1981-02       Impact factor: 8.694

5.  Combined deficiency of apolipoprotein C-II and lipoprotein lipase in familial hyperchylomicronemia.

Authors:  A F Stalenhoef; A F Casparie; P N Demacker; J T Stouten; J A Lutterman; A van 't Laar
Journal:  Metabolism       Date:  1981-09       Impact factor: 8.694

6.  Changing relative proportions of apolipoproteins CII and CIII of very low density lipoproteins in hypertriglyceridaemia.

Authors:  L A Carlson; D Ballantyne
Journal:  Atherosclerosis       Date:  1976 May-Jun       Impact factor: 5.162

7.  The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type IV subjects.

Authors:  A L Catapano
Journal:  Atherosclerosis       Date:  1980-04       Impact factor: 5.162

8.  Radioimmunoassay of human apolipoprotein CII. A study in normal and hypertriglyceridemic subjects.

Authors:  M L Kashyap; L S Srivastava; C Y Chen; C G Perisutti; M Campbell; R F Lutmer; C J Glueck
Journal:  J Clin Invest       Date:  1977-07       Impact factor: 14.808

9.  Serum lipids and apoprotein composition (%) of the very low density lipoprotein (VLDL) fraction in two groups of diabetic patients: effects of oral as compared to insulin therapy.

Authors:  A Pagnan; D Padovan; P Guarini; N Teodoro; G Zanetti
Journal:  Acta Diabetol Lat       Date:  1980 Jul-Dec

10.  Composition of serum very-low-density and high-density lipoproteins in diabetes.

Authors:  J Gabor; M Spain; N Kalant
Journal:  Clin Chem       Date:  1980-08       Impact factor: 8.327
  10 in total
  7 in total

1.  The distribution profiles of very low density and low density lipoproteins in poorly-controlled male, type 2 (non-insulin-dependent) diabetic patients.

Authors:  R W James; D Pometta
Journal:  Diabetologia       Date:  1991-04       Impact factor: 10.122

Review 2.  Lipoprotein alterations in diabetes mellitus.

Authors:  G M Kostner; I Karádi
Journal:  Diabetologia       Date:  1988-10       Impact factor: 10.122

3.  Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes.

Authors:  Anne Hiukka; Jamila Fruchart-Najib; Eeva Leinonen; Hannele Hilden; Jean-Charles Fruchart; Marja-Riitta Taskinen
Journal:  Diabetologia       Date:  2005-04-30       Impact factor: 10.122

Review 4.  Diabetic dyslipidaemia: from basic research to clinical practice.

Authors:  M-R Taskinen
Journal:  Diabetologia       Date:  2003-05-28       Impact factor: 10.122

5.  Metabolism of very low- and low-density lipoproteins isolated from normolipidaemic type 2 (non-insulin-dependent) diabetic patients by human monocyte-derived macrophages.

Authors:  R L Klein; T J Lyons; M F Lopes-Virella
Journal:  Diabetologia       Date:  1990-05       Impact factor: 10.122

6.  HDL Containing Apolipoprotein C-III is Associated with Insulin Sensitivity: A Multicenter Cohort Study.

Authors:  Rain Yamamoto; Majken K Jensen; Sarah Aroner; Jeremy D Furtado; Bernard Rosner; Frank B Hu; Beverley Balkau; Andrea Natali; Ele Ferrannini; Simona Baldi; Frank M Sacks
Journal:  J Clin Endocrinol Metab       Date:  2021-07-13       Impact factor: 5.958

7.  Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons.

Authors:  M van Hoek; T W van Herpt; A Dehghan; A Hofman; A G Lieverse; C M van Duijn; J C M Witteman; E J G Sijbrands
Journal:  Diabetologia       Date:  2011-03-04       Impact factor: 10.122
  7 in total

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