Literature DB >> 7104194

The site of binding of anti-CEA antibodies to tumour CEA in vivo: an immunocytochemical and autoradiographic approach.

V Moshakis, M G Ormerod, J H Westwood, S Imrie, A M Neville.   

Abstract

Radiolabelled affinity-purified antibody to carcinoembryonic antigen (CEA) was injected i.v. into immune-suppressed mice carrying xenografts of human breast carcinoma. Its distribution in the tumours was examined by a combination of immunocytochemistry and autoradiography. The antibody interacted predominantly with the CEA in the extracellular tumour space, rather than on the cell membrane or cytoplasm.

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Year:  1982        PMID： 7104194      PMCID： PMC2011056          DOI： 10.1038/bjc.1982.159

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

1.  In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice.

Authors:  J P Mach; S Carrel; C Merenda; B Sordat; J C Cerottini
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

2.  Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen.

Authors:  F J Primus; R H Wang; D M Goldenberg; H J Hansen
Journal:  Cancer Res       Date:  1973-11       Impact factor: 12.701

3.  Specific in vivo localization of monoclonal antibodies directed against the Thy 1.1 antigen.

Authors:  L L Houston; R C Nowinski; I D Bernstein
Journal:  J Immunol       Date:  1980-08       Impact factor: 5.422

4.  Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen.

Authors:  D M Goldenberg; E E Kim; F H DeLand; S Bennett; F J Primus
Journal:  Cancer Res       Date:  1980-08       Impact factor: 12.701

5.  Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy.

Authors:  B Ballou; G Levine; T R Hakala; D Solter
Journal:  Science       Date:  1979-11-16       Impact factor: 47.728

6.  Factors affecting the expression of carcinoembryonic antigen at the surface of cultured human colon carcinoma cells.

Authors:  K L Rosenthal; W A Tompkins; W E Rawls
Journal:  Cancer Res       Date:  1980-12       Impact factor: 12.701

7.  Radioimmunodetection of cancer with radiolabeled antibodies to alpha-fetoprotein.

Authors:  E E Kim; F H DeLand; M O Nelson; S Bennett; G Simmons; E Alpert; D M Goldenberg
Journal:  Cancer Res       Date:  1980-08       Impact factor: 12.701

8.  Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen.

Authors:  P W Dykes; K R Hine; A R Bradwell; J C Blackburn; T A Reeder; Z Drolc; S N Booth
Journal:  Br Med J       Date:  1980-01-26

9.  Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.

Authors:  J P Mach; S Carrel; M Forni; J Ritschard; A Donath; P Alberto
Journal:  N Engl J Med       Date:  1980-07-03       Impact factor: 91.245

10.  Improved immune-suppression techniques for the exongrafting of human tumours.

Authors:  G G Steel; V D Courtenay; A Y Rostom
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640
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  8 in total

1.  Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.

Authors:  E N Kaufman; R K Jain
Journal:  Biophys J       Date:  1990-10       Impact factor: 4.033

2.  Immunoautoradiographic and protein-A/gold labelling experiments for localization of pollen allergens using antisera from atopic human individuals.

Authors:  H G Fromme; M Grote; N J Sinclair; K Kalveram
Journal:  Histochemistry       Date:  1985

3.  Analysis of a conjugate between anti-carcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate.

Authors:  H J Haisma; E Boven; M van Muijen; R De Vries; H M Pinedo
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

Review 4.  Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.

Authors:  C H Ford; A G Casson
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

5.  The detection of virally induced tumors by 131I- and 125I-labeled syngeneic monoclonal antibodies.

Authors:  D Berends; J L van Gaalen; E H Rhijnsburger; N J de Both; W Breeman; W H Bakker; P Kooy
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

6.  A prospective study of the use of 111In-labelled monoclonal antibody against carcino-embryonic antigen in colorectal cancer and of some biological factors affecting its uptake.

Authors:  M Granowska; J R Jass; K E Britton; J M Northover
Journal:  Int J Colorectal Dis       Date:  1989       Impact factor: 2.571

Review 7.  Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting.

Authors:  R W Baldwin; M V Pimm
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

Review 8.  Scanning for tumours with radiolabelled antibodies: a review.

Authors:  P W Dykes; A R Bradwell; D S Fairweather
Journal:  J R Soc Med       Date:  1983-11       Impact factor: 18.000
  8 in total

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