Literature DB >> 7104184

Cimetidine does not increase the anticoagulant effect of phenprocoumon.

J Harenberg, C Staiger, J X de Vries, E Walter, E Weber, R Zimmermann.   

Abstract

In patients on oral warfarin, nicoumalone and phenindione an increase of the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore we have investigated the effect of cimetidine on the steady state dynamics of phenprocoumon in ten outpatients. No changes in the anticoagulant effect and the plasma phenprocoumon levels were observed during and after 2 weeks application of cimetidine. The data show that cimetidine does not interact with the metabolism of phenprocoumon in contrast to warfarin.

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Year:  1982        PMID： 7104184      PMCID： PMC1427747          DOI： 10.1111/j.1365-2125.1982.tb01979.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  4 in total

1.  Thrombotest. A new method for controlling anticoagulant therapy.

Authors:  P A OWREN
Journal:  Lancet       Date:  1959-11-07       Impact factor: 79.321

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Authors:  M J Serlin; M Challiner; B K Park; P A Turcan; A M Breckenridge
Journal:  Biochem Pharmacol       Date:  1980-07-01       Impact factor: 5.858

3.  Pharmacokinetics of phenprocoumon in man investigated using a gas chromatographic method of drug analysis.

Authors:  N Heni; P Glogner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

4.  Cimetidine: interaction with oral anticoagulants in man.

Authors:  M J Serlin; R G Sibeon; S Mossman; A M Breckenridge; J R Williams; J L Atwood; J M Willoughby
Journal:  Lancet       Date:  1979-08-18       Impact factor: 79.321
  4 in total
  6 in total

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2.  Drug interactions through binding to cytochrome p 450: the experience with h2-receptor blocking agents.

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Review 3.  Haematological adverse effects of histamine H2-receptor antagonists.

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4.  Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro.

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Journal:  Eur J Clin Pharmacol       Date:  2004-03-31       Impact factor: 2.953

5.  Lack of effect of cimetidine on pharmacodynamics and kinetics of single oral doses of R- and S-acenocoumarol.

Authors:  H H Thijssen; G M Janssen; L G Baars
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

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  6 in total

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