Literature DB >> 7104181

Metabolism of digoxin and absorption site.

J O Magnusson, B Bergdahl, C Bogentoft, U E Jonsson.   

Abstract

After oral intake of enteric-coated granules containing [3H]-digoxin extensive metabolism was observed. Maximum 66% of the 24 h urinary excretion was identified as [3H]-dihydrodigoxin, using high performance liquid chromatography for the analysis. It is suggested that metabolism of digoxin may depend on the absorption site.

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Year:  1982        PMID： 7104181      PMCID： PMC1427753          DOI： 10.1111/j.1365-2125.1982.tb01976.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  6 in total

1.  Bioavailability of digoxin.

Authors:  A Bertler; A Redfors; S Medin; L Nyberg
Journal:  Lancet       Date:  1972-09-30       Impact factor: 79.321

2.  The absorption of orally administered (12 - 3 H)digoxin in man.

Authors:  B Beermann; K Hellström; A Rosén
Journal:  Clin Sci       Date:  1972-10       Impact factor: 6.124

3.  Urinary excretion of reduced metabolites of digoxin.

Authors:  J Lindenbaum; D Tse-Eng; V P Butler; D G Rund
Journal:  Am J Med       Date:  1981-07       Impact factor: 4.965

4.  Determination of tritiated digoxin and metabolites in urine by liquid chromatography.

Authors:  B M Eriksson; L Tekenbergs; J O Magnusson; L Molin
Journal:  J Chromatogr       Date:  1981-05-08

5.  Inactivation of digoxin by the gut flora: reversal by antibiotic therapy.

Authors:  J Lindenbaum; D G Rund; V P Butler; D Tse-Eng; J R Saha
Journal:  N Engl J Med       Date:  1981-10-01       Impact factor: 91.245

6.  Absorption of digoxin from a new microencapsulated formulation.

Authors:  B Bergdahl; C Bogentoft; U E Jonsson; J O Magnusson
Journal:  Eur J Clin Pharmacol       Date:  1980-06       Impact factor: 2.953
  6 in total
  6 in total

Review 1.  Bioavailability Based on the Gut Microbiota: a New Perspective.

Authors:  Feng Zhang; Fang He; Li Li; Lichun Guo; Bin Zhang; Shuhuai Yu; Wei Zhao
Journal:  Microbiol Mol Biol Rev       Date:  2020-04-29       Impact factor: 11.056

2.  Fasting and postprandial absorption of digoxin from a microencapsulated formulation.

Authors:  B Bergdahl; C Bogentoft; U E Jonsson; J O Magnusson
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

3.  Metabolism of digoxin after oral and intrajejunal administration.

Authors:  J O Magnusson
Journal:  Br J Clin Pharmacol       Date:  1983-12       Impact factor: 4.335

4.  Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man.

Authors:  R Huupponen; P Seppälä; E Iisalo
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

5.  Xenobiotics shape the physiology and gene expression of the active human gut microbiome.

Authors:  Corinne Ferrier Maurice; Henry Joseph Haiser; Peter James Turnbaugh
Journal:  Cell       Date:  2013-01-17       Impact factor: 41.582

6.  Increased metabolism to dihydrodigoxin after intake of a microencapsulated formulation of digoxin.

Authors:  J O Magnusson; B Bergdahl; C Bogentoft; S Gustafsson; U E Jonsson
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953
  6 in total

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