Literature DB >> 7104161

Tooth pulp stimulation: a method of determining the analgesic efficacy of meptazinol in man.

J Gabka, R K Price.   

Abstract

A dose-ranging study of meptazinol was carried out using the pain threshold to electrical tooth pulp stimulation in healthy volunteers as the pain model. A well defined dose-response curve was found for oral meptazinol (50 mg, 100 mg, 150 mg and 200 mg) and placebo. The methodology and results are discussed in terms of subsequent clinical experience with meptazinol.

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Year:  1982        PMID： 7104161      PMCID： PMC1427570          DOI： 10.1111/j.1365-2125.1982.tb04943.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  8 in total

Review 1.  A review of the biological properties and metabolic disposition of the new analgesic agent, meptazinol.

Authors:  R J Stephens; J F Waterfall; R A Franklin
Journal:  Gen Pharmacol       Date:  1978

2.  [Experimental studies and chemical testing of the morphine antagonist pentazocine].

Authors:  J Gabka
Journal:  Med Monatsschr       Date:  1971-04

3.  [Clinical experimental measurements of stimulus threshold using a new analgesic].

Authors:  J Gabka
Journal:  Dtsch Med J       Date:  1972-11-10

4.  A double blind comparison of meptazinol versus pentazocine in chronic rheumatoid and osteoarthritis.

Authors:  S G Flavell-Matts; P J Ward
Journal:  Br J Clin Pract       Date:  1980-10

5.  Analgesic methodology: a brief history and commentary.

Authors:  L Lasagna
Journal:  J Clin Pharmacol       Date:  1980 May-Jun       Impact factor: 3.126

6.  The clinical assessment of analgesic drugs.

Authors:  D W Littlejohns; D W Vere
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

7.  Double-blind crossover trial of oral meptazinol, pentazocine and placebo in the treatment of pain in the elderly.

Authors:  V Pearce; P J Robson
Journal:  Postgrad Med J       Date:  1980-07       Impact factor: 2.401

8.  First impressions of the use of meptazinol in general practice.

Authors:  A G Wade; P J Ward
Journal:  J Int Med Res       Date:  1981       Impact factor: 1.671
  8 in total
  4 in total

1.  Increase of pain threshold by calcitonin during electrical stimulation of the dental pulp. Investigations in healthy volunteers with regard to plasma concentration.

Authors:  K Welzel; D Welzel
Journal:  Schmerz       Date:  1989-09       Impact factor: 1.107

2.  Placebo and Active Treatment Additivity in Placebo Analgesia: Research to Date and Future Directions.

Authors:  Matthew J Coleshill; Louise Sharpe; Luana Colloca; Robert Zachariae; Ben Colagiuri
Journal:  Int Rev Neurobiol       Date:  2018-08-06       Impact factor: 3.230

3.  Effects of graded oral doses of meptazinol and pentazocine in comparison with placebo on experimentally induced pain in healthy humans.

Authors:  G Stacher; H Steinringer; S Winklehner; G Mittelbach; C Schneider
Journal:  Br J Clin Pharmacol       Date:  1983-08       Impact factor: 4.335

Review 4.  Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.

Authors:  B Holmes; A Ward
Journal:  Drugs       Date:  1985-10       Impact factor: 9.546
  4 in total

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