Literature DB >> 710403

Ecdysone oxidase: reaction and specificity.

J Koolman, P Karlson.   

Abstract

Ecdysone oxidase oxidizes 3-hydroxysteroids of the excysteroid type irreversibly to 3-dehydro derivatives. The hydrogen of the steroid is transferred by the enzyme to oxygen which is reduced to hydrogen peroxide. Ecdysone oxidase is relatively specific for ecdysone and ecdysterone. Apparent Michaelis constants for these two physiological substrates are 98 and 31 micron, respectively. Cholesterol oxidase and 3alpha-hydroxysteroid and 3beta-hydroxysteroid dehydrogenases which catalyze similar reactions are unable to oxidize ecdysteroids.

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Year:  1978        PMID： 710403     DOI： 10.1111/j.1432-1033.1978.tb12548.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  5 in total

1.  Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration.

Authors:  Hajime Takeuchi; Daniel J Rigden; Bahram Ebrahimi; Philip C Turner; Huw H Rees
Journal:  Biochem J       Date:  2005-08-01       Impact factor: 3.857

2.  Prothoracic gland synthesis of 3-dehydroecdysone and its hemolymph 3 beta-reductase mediated conversion to ecdysone in representative insects.

Authors:  S Kiriishi; D B Rountree; S Sakurai; L I Gilbert
Journal:  Experientia       Date:  1990-07-15

3.  Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori.

Authors:  Zhiqian Li; Lang You; Baosheng Zeng; Lin Ling; Jun Xu; Xu Chen; Zhongjie Zhang; Subba Reddy Palli; Yongping Huang; Anjiang Tan
Journal:  Proc Biol Sci       Date:  2015-06-22       Impact factor: 5.349

4.  Enzymes of ecdysteroid transformation and inactivation in the midgut of the cotton leafworm, Spodoptera littoralis: properties and developmental profiles.

Authors:  T J Webb; R Powls; H H Rees
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

5.  Involvement of 3-dehydroecdysone in the 3-epimerization of ecdysone.

Authors:  N P Milner; H H Rees
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857
  5 in total

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