Cingulate damage attenuates conditioned bradycardia.

New Zealand albino rabbits received either sham, midline cortical, lateral cortical, or combined medial-lateral cortical lesions, and were subjected to differential pavlovian conditioning in which tones of different frequencies served as the conditioning stimulus and a brief paraorbital electric shock train served as the unconditioned stimulus. Heart rate conditioned responses were recorded.d Damage to medial but not lateral neocortex abolished the heart rate conditioned response. These data suggest that midline cortical structures may modulate higher level processing of stimulus information.